284106

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 332046..332587 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QRM70_RS01795 Protein ID WP_000615976.1
Coordinates 332309..332587 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QRM70_RS01790 Protein ID WP_000729704.1
Coordinates 332046..332306 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS01765 (327829) 327829..328614 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
QRM70_RS01770 (328586) 328586..330298 + 1713 Protein_326 flagellar biosynthesis protein FlhA -
QRM70_RS01775 (330403) 330403..330681 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QRM70_RS01780 (330674) 330674..331030 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
QRM70_RS01785 (331087) 331087..331860 - 774 WP_000543895.1 C40 family peptidase -
QRM70_RS01790 (332046) 332046..332306 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QRM70_RS01795 (332309) 332309..332587 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QRM70_RS01800 (332743) 332743..333483 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QRM70_RS01805 (333454) 333454..334221 - 768 WP_000333380.1 class II glutamine amidotransferase -
QRM70_RS01810 (334427) 334427..335005 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 330674..348573 17899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T284106 WP_000615976.1 NZ_CP127306:332309-332587 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT284106 WP_000729704.1 NZ_CP127306:332046-332306 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References