284097

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2316229..2316770 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag QRM68_RS12655 Protein ID WP_000615980.1
Coordinates 2316229..2316507 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag QRM68_RS12660 Protein ID WP_000729709.1
Coordinates 2316510..2316770 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS12640 (2313811) 2313811..2314389 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
QRM68_RS12645 (2314595) 2314595..2315362 + 768 WP_000333379.1 class II glutamine amidotransferase -
QRM68_RS12650 (2315333) 2315333..2316073 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QRM68_RS12655 (2316229) 2316229..2316507 - 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QRM68_RS12660 (2316510) 2316510..2316770 - 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QRM68_RS12665 (2316980) 2316980..2317729 + 750 WP_000056850.1 C40 family peptidase -
QRM68_RS12670 (2317905) 2317905..2318401 + 497 Protein_2181 REP-associated tyrosine transposase RayT -
QRM68_RS12675 (2318594) 2318594..2320687 - 2094 WP_021556448.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T284097 WP_000615980.1 NZ_CP127303:c2316507-2316229 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT284097 WP_000729709.1 NZ_CP127303:c2316770-2316510 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References