Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 570307..571106 Replicon chromosome
Accession NZ_CP127303
Organism Escherichia coli strain APEC37

Toxin (Protein)


Gene name yhaV Uniprot ID A0A161R7C1
Locus tag QRM68_RS04240 Protein ID WP_000347278.1
Coordinates 570642..571106 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QRM68_RS04235 Protein ID WP_001307405.1
Coordinates 570307..570642 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM68_RS04220 (566092) 566092..566862 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QRM68_RS04225 (566878) 566878..568212 - 1335 WP_000599633.1 galactarate/glucarate/glycerate transporter GarP -
QRM68_RS04230 (568587) 568587..570158 + 1572 WP_001273763.1 galactarate dehydratase -
QRM68_RS04235 (570307) 570307..570642 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QRM68_RS04240 (570642) 570642..571106 + 465 WP_000347278.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QRM68_RS04245 (571161) 571161..571970 - 810 WP_000072174.1 aga operon transcriptional regulator AgaR -
QRM68_RS04250 (572219) 572219..573499 + 1281 WP_021557243.1 tagatose-bisphosphate aldolase subunit KbaZ -
QRM68_RS04255 (573522) 573522..573995 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QRM68_RS04260 (574006) 574006..574785 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QRM68_RS04265 (574775) 574775..575653 + 879 WP_021557244.1 PTS N-acetylgalactosamine transporter subunit IID -
QRM68_RS04270 (575671) 575671..576105 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 561546..571106 9560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17866.28 Da        Isoelectric Point: 9.6924

>T284091 WP_000347278.1 NZ_CP127303:570642-571106 [Escherichia coli]
MDFPQRVNGWALYTHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT284091 WP_001307405.1 NZ_CP127303:570307-570642 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161R7C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References