Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4257852..4258393 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag QRM67_RS21115 Protein ID WP_000615979.1
Coordinates 4258115..4258393 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QRM67_RS21110 Protein ID WP_000729704.1
Coordinates 4257852..4258112 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS21085 (4253635) 4253635..4254420 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
QRM67_RS21090 (4254392) 4254392..4256104 + 1713 Protein_4114 flagellar biosynthesis protein FlhA -
QRM67_RS21095 (4256209) 4256209..4256487 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QRM67_RS21100 (4256480) 4256480..4256836 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
QRM67_RS21105 (4256893) 4256893..4257666 - 774 WP_000543899.1 C40 family peptidase -
QRM67_RS21110 (4257852) 4257852..4258112 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QRM67_RS21115 (4258115) 4258115..4258393 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QRM67_RS21120 (4258549) 4258549..4259289 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QRM67_RS21125 (4259260) 4259260..4260027 - 768 WP_000333380.1 class II glutamine amidotransferase -
QRM67_RS21130 (4260233) 4260233..4260811 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T284068 WP_000615979.1 NZ_CP127297:4258115-4258393 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT284068 WP_000729704.1 NZ_CP127297:4257852-4258112 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References