Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2227060..2227562 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QRM67_RS10745 Protein ID WP_000767829.1
Coordinates 2227308..2227562 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QRM67_RS10740 Protein ID WP_001259255.1
Coordinates 2227060..2227311 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS10715 (2222237) 2222237..2223305 - 1069 Protein_2076 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QRM67_RS10720 (2223305) 2223305..2224375 - 1071 WP_001564244.1 histidinol-phosphate transaminase -
QRM67_RS10725 (2224372) 2224372..2225676 - 1305 WP_040091442.1 histidinol dehydrogenase -
QRM67_RS10730 (2225682) 2225682..2226581 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QRM67_RS10735 (2226727) 2226727..2226777 - 51 WP_001364200.1 his operon leader peptide -
QRM67_RS10740 (2227060) 2227060..2227311 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QRM67_RS10745 (2227308) 2227308..2227562 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QRM67_RS10750 (2227645) 2227645..2228469 + 825 WP_054627086.1 SDR family oxidoreductase -
QRM67_RS10755 (2228515) 2228515..2229444 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QRM67_RS10760 (2229658) 2229658..2229720 + 63 WP_010723108.1 membrane protein YoeI -
QRM67_RS10765 (2229710) 2229710..2231068 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QRM67_RS10770 (2231247) 2231247..2232305 + 1059 WP_000492340.1 thiosulfate utilization transporter TsuA/YeeE -
QRM67_RS10775 (2232319) 2232319..2232546 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T284058 WP_000767829.1 NZ_CP127297:2227308-2227562 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT284058 WP_001259255.1 NZ_CP127297:2227060-2227311 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References