Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 940769..941568 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag QRM67_RS04525 Protein ID WP_000347267.1
Coordinates 940769..941233 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QRM67_RS04530 Protein ID WP_001307405.1
Coordinates 941233..941568 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS04495 (935770) 935770..936204 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QRM67_RS04500 (936222) 936222..937100 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QRM67_RS04505 (937090) 937090..937869 - 780 WP_054627033.1 PTS N-acetylgalactosamine transporter subunit IIC -
QRM67_RS04510 (937880) 937880..938353 - 474 WP_222699509.1 PTS N-acetylgalactosamine transporter subunit IIB -
QRM67_RS04515 (938376) 938376..939656 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QRM67_RS04520 (939905) 939905..940714 + 810 WP_000072193.1 aga operon transcriptional regulator AgaR -
QRM67_RS04525 (940769) 940769..941233 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QRM67_RS04530 (941233) 941233..941568 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QRM67_RS04535 (941717) 941717..943289 - 1573 Protein_868 galactarate dehydratase -
QRM67_RS04540 (943664) 943664..944998 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QRM67_RS04545 (945014) 945014..945784 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T284053 WP_000347267.1 NZ_CP127297:c941233-940769 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT284053 WP_001307405.1 NZ_CP127297:c941568-941233 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References