Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 143508..144110 Replicon chromosome
Accession NZ_CP127297
Organism Escherichia coli strain APEC20/16

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QRM67_RS00645 Protein ID WP_205899241.1
Coordinates 143799..144110 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRM67_RS00640 Protein ID WP_000356397.1
Coordinates 143508..143798 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM67_RS00615 (139434) 139434..140336 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QRM67_RS00620 (140333) 140333..140968 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QRM67_RS00625 (140965) 140965..141894 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QRM67_RS00630 (142224) 142224..142466 - 243 WP_001086388.1 protein YiiF -
QRM67_RS00635 (142685) 142685..142903 - 219 WP_001295676.1 CopG family transcriptional regulator -
QRM67_RS00640 (143508) 143508..143798 - 291 WP_000356397.1 NadS family protein Antitoxin
QRM67_RS00645 (143799) 143799..144110 - 312 WP_205899241.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRM67_RS00650 (144339) 144339..145247 + 909 WP_001162704.1 alpha/beta hydrolase -
QRM67_RS00655 (145311) 145311..146252 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QRM67_RS00660 (146297) 146297..146734 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QRM67_RS00665 (146731) 146731..147603 - 873 WP_000920762.1 virulence factor BrkB family protein -
QRM67_RS00670 (147597) 147597..148196 - 600 WP_001315111.1 glucose-1-phosphatase -
QRM67_RS00675 (148295) 148295..149080 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12189.21 Da        Isoelectric Point: 10.0241

>T284051 WP_205899241.1 NZ_CP127297:c144110-143799 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDNLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT284051 WP_000356397.1 NZ_CP127297:c143798-143508 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References