Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6445799..6446475 Replicon chromosome
Accession NZ_CP127296
Organism Amycolatopsis sp. DG1A-15b

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag QRY02_RS29555 Protein ID WP_285986107.1
Coordinates 6446113..6446475 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRY02_RS29550 Protein ID WP_285986106.1
Coordinates 6445799..6446116 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRY02_RS29535 (QRY02_29535) 6442222..6442908 - 687 WP_285986103.1 LPXTG cell wall anchor domain-containing protein -
QRY02_RS29540 (QRY02_29540) 6443177..6444703 - 1527 WP_285986104.1 amino acid permease -
QRY02_RS29545 (QRY02_29545) 6444796..6445713 - 918 WP_285986105.1 cation diffusion facilitator family transporter -
QRY02_RS29550 (QRY02_29550) 6445799..6446116 - 318 WP_285986106.1 helix-turn-helix transcriptional regulator Antitoxin
QRY02_RS29555 (QRY02_29555) 6446113..6446475 - 363 WP_285986107.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRY02_RS29560 (QRY02_29560) 6446595..6449522 + 2928 WP_285986108.1 BTAD domain-containing putative transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13587.39 Da        Isoelectric Point: 4.5268

>T284050 WP_285986107.1 NZ_CP127296:c6446475-6446113 [Amycolatopsis sp. DG1A-15b]
MAGQDWEIYVVDEVLEWIERLDDATHARVVQAIDALAEGGPGLGRPLVDTIVGSRIQNLKELRPGTVRILFVFDPWRASV
LLVAGDKAGRWNAWYGEAIPLAEDRYDRYLKERQAEEGRP

Download         Length: 363 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11427.98 Da        Isoelectric Point: 9.6206

>AT284050 WP_285986106.1 NZ_CP127296:c6446116-6445799 [Amycolatopsis sp. DG1A-15b]
MTGYTRWKDVRATHVERAGGEEAVEAGKQELLAVVQGHRLAEIRRGRGLTQQQLADRMGVTKGRVSQIEQGKISGLEVLA
RYAAALGGRLHQAIYFEDGDIAAIA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References