Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3783952..3784619 Replicon chromosome
Accession NZ_CP127276
Organism Mycobacterium tuberculosis strain 5521

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag QRF08_RS17865 Protein ID WP_003417916.1
Coordinates 3783952..3784344 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag QRF08_RS17870 Protein ID WP_003912214.1
Coordinates 3784344..3784619 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF08_RS17845 (QRF08_17845) 3779521..3779700 - 180 WP_250575601.1 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
QRF08_RS17855 (QRF08_17855) 3781157..3782146 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
QRF08_RS17860 (QRF08_17860) 3782146..3783198 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
QRF08_RS17865 (QRF08_17865) 3783952..3784344 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF08_RS17870 (QRF08_17870) 3784344..3784619 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QRF08_RS17875 (QRF08_17875) 3784801..3786172 + 1372 Protein_3531 ISNCY family transposase -
QRF08_RS17880 (QRF08_17880) 3786362..3788557 + 2196 WP_070895318.1 PE family protein -
QRF08_RS17885 (QRF08_17885) 3788628..3789500 - 873 WP_003906098.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3779809..3786172 6363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T283987 WP_003417916.1 NZ_CP127276:c3784344-3783952 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT283987 WP_003912214.1 NZ_CP127276:c3784619-3784344 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References