Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4794170..4794741 Replicon chromosome
Accession NC_018691
Organism Alcanivorax dieselolei B5

Toxin (Protein)


Gene name higB Uniprot ID A0A154C0S4
Locus tag B5T_RS21485 Protein ID WP_026948751.1
Coordinates 4794170..4794448 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag B5T_RS21490 Protein ID WP_014996637.1
Coordinates 4794448..4794741 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5T_RS21460 4789177..4789986 - 810 WP_014996631.1 mechanosensitive ion channel -
B5T_RS21465 4790138..4790614 - 477 WP_014996632.1 peroxiredoxin -
B5T_RS21470 4790814..4792829 - 2016 WP_202803088.1 VIT and VWA domain-containing protein -
B5T_RS21475 4793017..4793532 - 516 WP_014996634.1 hypothetical protein -
B5T_RS21480 4793563..4794048 - 486 WP_014996635.1 YajQ family cyclic di-GMP-binding protein -
B5T_RS21485 4794170..4794448 + 279 WP_026948751.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5T_RS21490 4794448..4794741 + 294 WP_014996637.1 HigA family addiction module antidote protein Antitoxin
B5T_RS21495 4794837..4795436 + 600 WP_014996638.1 tRNA (pseudouridine(54)-N(1))-methyltransferase TrmY -
B5T_RS21500 4795455..4796120 - 666 WP_014996639.1 thiopurine S-methyltransferase -
B5T_RS21505 4796189..4798954 - 2766 WP_014996640.1 DNA polymerase I -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-92)

Antitoxin

(1-85)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10532.07 Da        Isoelectric Point: 10.5861

>T28389 WP_026948751.1 NC_018691:4794170-4794448 [Alcanivorax dieselolei B5]
MIKSFRHKGLQRFFTTGSTAGVQTTHAKRLRMQLAALDTATVIEDMDIPGFSLHPLKGKAKGRWSIRVSGNWRLTFEFKD
GNAYVLNYEDYH

Download         Length: 279 bp

>T28389 NC_018691:4794170-4794448 [Alcanivorax dieselolei B5]
ATGATCAAATCATTCCGCCACAAAGGACTGCAGCGGTTTTTCACCACCGGCTCCACCGCCGGTGTTCAAACCACTCATGC
CAAGCGTCTGAGGATGCAACTGGCCGCCCTGGATACCGCAACGGTCATTGAGGATATGGATATCCCGGGCTTCTCCTTGC
ACCCCTTGAAAGGAAAAGCAAAGGGGCGCTGGTCCATCCGGGTAAGCGGAAACTGGCGTCTGACCTTTGAATTCAAGGAC
GGCAACGCCTATGTGTTGAACTACGAGGATTATCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10827.49 Da        Isoelectric Point: 8.6425

>AT28389 WP_014996637.1 NC_018691:4794448-4794741 [Alcanivorax dieselolei B5]
MNMHHPPHPGEFIREVYLEPHGLSVRALAAKLDISPSSLSRVLNGASGVSPEMALRLSKALGRTPESWLALQDLYDLWQA
RQRINLDKVQAIDFKVA

Download         Length: 294 bp

>AT28389 NC_018691:4794448-4794741 [Alcanivorax dieselolei B5]
ATGAACATGCACCATCCCCCACACCCCGGTGAGTTCATCCGAGAGGTCTACCTGGAACCTCACGGTTTAAGTGTGCGTGC
GCTGGCGGCAAAGCTGGATATCTCTCCCTCCTCGCTCAGTCGCGTCCTTAACGGGGCCAGCGGCGTGAGCCCGGAAATGG
CTTTGCGCCTATCAAAAGCCCTGGGGCGAACTCCGGAAAGCTGGCTGGCCTTGCAGGACCTTTACGACCTCTGGCAGGCA
CGGCAACGGATCAATCTGGACAAGGTCCAGGCCATCGATTTCAAGGTTGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A154C0S4


Antitoxin

Source ID Structure

References