Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1853520..1854157 Replicon chromosome
Accession NC_018691
Organism Alcanivorax dieselolei B5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B5T_RS08490 Protein ID WP_041716946.1
Coordinates 1853520..1853813 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B5T_RS08495 Protein ID WP_041716947.1
Coordinates 1853828..1854157 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5T_RS08470 1848848..1850425 + 1578 WP_014992699.1 IS66 family transposase -
B5T_RS08475 1850507..1851085 + 579 WP_014994079.1 ComF family protein -
B5T_RS08480 1851082..1851642 + 561 WP_014994080.1 hypothetical protein -
B5T_RS08485 1851932..1853191 + 1260 WP_014994081.1 O-antigen ligase family protein -
B5T_RS08490 1853520..1853813 + 294 WP_041716946.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5T_RS08495 1853828..1854157 + 330 WP_041716947.1 HigA family addiction module antidote protein Antitoxin
B5T_RS22530 1854303..1854545 - 243 WP_014994084.1 addiction module protein -
B5T_RS22535 1854932..1855849 - 918 WP_202803037.1 TRAP transporter large permease subunit -
B5T_RS23495 1855755..1856249 - 495 WP_051015460.1 TRAP transporter large permease subunit -
B5T_RS08505 1856242..1856772 - 531 WP_014994085.1 TRAP transporter small permease subunit -
B5T_RS08510 1856775..1857911 - 1137 WP_014994086.1 TRAP transporter substrate-binding protein DctP -
B5T_RS08515 1858060..1858482 - 423 WP_014994087.1 OB-fold domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - bplB 1826825..1856772 29947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-70)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11331.71 Da        Isoelectric Point: 5.6334

>T28385 WP_041716946.1 NC_018691:1853520-1853813 [Alcanivorax dieselolei B5]
MAVEFRDVWLEAFYENSQSHRRIPSTIEGALFRKLEILDAATRESDLRSSPGNRFEHLEGNLDGWCSIRVNKQYRLIFEW
IDGVAQGTYLDPHIYKG

Download         Length: 294 bp

>T28385 NC_018691:1853520-1853813 [Alcanivorax dieselolei B5]
ATGGCTGTCGAATTCAGGGACGTGTGGCTGGAGGCGTTTTACGAGAATAGCCAAAGCCATCGGAGGATACCCAGTACCAT
CGAAGGGGCATTGTTCAGGAAGCTGGAGATCCTGGACGCGGCGACCCGGGAGTCTGACTTGAGGAGCTCTCCGGGGAATC
GGTTCGAGCACCTTGAAGGAAATCTGGACGGGTGGTGTTCTATCCGGGTAAACAAGCAGTACCGCCTGATCTTCGAATGG
ATCGATGGCGTTGCTCAAGGCACTTATCTGGATCCTCATATCTACAAGGGCTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12268.16 Da        Isoelectric Point: 10.4371

>AT28385 WP_041716947.1 NC_018691:1853828-1854157 [Alcanivorax dieselolei B5]
MRNTRRRPVTVGEMLVSEFLEPMNIEIGELAEAMGVHRNTLSRIVHDKGVLTAPMAIKLAAALGNTPEFWLNIQHAVALW
DVRQSAHEHEARNVRRVTGHLENRKAATL

Download         Length: 330 bp

>AT28385 NC_018691:1853828-1854157 [Alcanivorax dieselolei B5]
ATGCGGAACACAAGACGTCGTCCGGTCACGGTTGGCGAGATGCTGGTGAGCGAGTTCCTGGAGCCCATGAATATCGAAAT
CGGTGAGCTGGCCGAGGCAATGGGCGTCCACAGGAACACGTTGAGCCGGATCGTTCACGACAAAGGCGTTCTGACCGCCC
CCATGGCGATCAAGTTGGCCGCGGCCTTGGGGAACACCCCGGAATTCTGGCTCAATATTCAACACGCGGTGGCGTTGTGG
GATGTACGCCAGAGTGCCCATGAGCATGAAGCGAGAAACGTGAGAAGAGTCACGGGGCACTTGGAGAATAGAAAAGCGGC
GACTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References