Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2185653..2186521 Replicon chromosome
Accession NZ_CP127274
Organism Mycobacterium tuberculosis strain 17221

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag QRF10_RS10225 Protein ID WP_010886136.1
Coordinates 2185653..2186030 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRF10_RS10230 Protein ID WP_003913306.1
Coordinates 2186072..2186521 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF10_RS10175 (QRF10_10175) 2181442..2181894 - 453 WP_003899095.1 lipoprotein -
QRF10_RS10180 (QRF10_10180) 2181958..2182359 + 402 WP_003409869.1 hypothetical protein -
QRF10_RS10185 (QRF10_10185) 2182352..2182534 - 183 WP_003409870.1 hypothetical protein -
QRF10_RS10190 (QRF10_10190) 2182648..2182998 - 351 WP_003899096.1 hypothetical protein -
QRF10_RS10195 (QRF10_10195) 2183009..2183911 - 903 WP_003899097.1 hypothetical protein -
QRF10_RS10200 (QRF10_10200) 2183932..2184123 - 192 WP_003409876.1 hypothetical protein -
QRF10_RS10205 (QRF10_10205) 2184124..2184420 - 297 WP_003409877.1 hypothetical protein -
QRF10_RS10210 (QRF10_10210) 2184660..2184875 + 216 WP_003409878.1 antitoxin -
QRF10_RS10215 (QRF10_10215) 2184872..2185183 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
QRF10_RS10220 (QRF10_10220) 2185157..2185678 - 522 WP_003904745.1 hypothetical protein -
QRF10_RS10225 (QRF10_10225) 2185653..2186030 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
QRF10_RS10230 (QRF10_10230) 2186072..2186521 + 450 WP_003913306.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
QRF10_RS10235 (QRF10_10235) 2186518..2187063 + 546 WP_003409891.1 SecB-like chaperone -
QRF10_RS10240 (QRF10_10240) 2186952..2187566 - 615 WP_003901296.1 hypothetical protein -
QRF10_RS10245 (QRF10_10245) 2187615..2187911 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
QRF10_RS10250 (QRF10_10250) 2187908..2188159 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
QRF10_RS10255 (QRF10_10255) 2188146..2188640 + 495 WP_003899099.1 hypothetical protein -
QRF10_RS10260 (QRF10_10260) 2188800..2189207 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
QRF10_RS10265 (QRF10_10265) 2189211..2189483 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QRF10_RS10270 (QRF10_10270) 2189516..2190736 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T283838 WP_010886136.1 NZ_CP127274:2185653-2186030 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16776.16 Da        Isoelectric Point: 8.0771

>AT283838 WP_003913306.1 NZ_CP127274:2186072-2186521 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVS

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure

References