283805

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3782220..3782887 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag QQ046_RS17815 Protein ID WP_003417916.1
Coordinates 3782220..3782612 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag QQ046_RS17820 Protein ID WP_003912214.1
Coordinates 3782612..3782887 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS17795 (QQ046_17795) 3777789..3777968 - 180 WP_250575601.1 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
QQ046_RS17805 (QQ046_17805) 3779425..3780414 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
QQ046_RS17810 (QQ046_17810) 3780414..3781466 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
QQ046_RS17815 (QQ046_17815) 3782220..3782612 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ046_RS17820 (QQ046_17820) 3782612..3782887 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QQ046_RS17825 (QQ046_17825) 3783069..3784440 + 1372 Protein_3521 ISNCY family transposase -
QQ046_RS17830 (QQ046_17830) 3784630..3786825 + 2196 WP_010886168.1 PE family protein -
QQ046_RS17835 (QQ046_17835) 3786896..3787768 - 873 WP_003906098.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3778077..3784440 6363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T283805 WP_003417916.1 NZ_CP127273:c3782612-3782220 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT283805 WP_003912214.1 NZ_CP127273:c3782887-3782612 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References