Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 8628746..8629398 Replicon chromosome
Accession NC_018681
Organism Nocardia brasiliensis ATCC 700358

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag O3I_RS38505 Protein ID WP_202805031.1
Coordinates 8628746..8629072 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag O3I_RS44355 Protein ID WP_041563143.1
Coordinates 8629069..8629398 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3I_RS38485 8624352..8625362 + 1011 WP_014988468.1 aldo/keto reductase -
O3I_RS38490 8625380..8625850 - 471 WP_014988469.1 DUF4442 domain-containing protein -
O3I_RS38495 8625966..8627027 - 1062 WP_041563141.1 glycerophosphodiester phosphodiesterase -
O3I_RS38500 8627087..8628049 - 963 WP_041563142.1 zinc-binding dehydrogenase -
O3I_RS38505 8628746..8629072 + 327 WP_202805031.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3I_RS44355 8629069..8629398 + 330 WP_041563143.1 helix-turn-helix domain-containing protein Antitoxin
O3I_RS38515 8629582..8630001 + 420 WP_141692077.1 hypothetical protein -
O3I_RS38520 8630003..8630527 - 525 WP_014988475.1 hypothetical protein -
O3I_RS38525 8630630..8630914 - 285 WP_014988476.1 hypothetical protein -
O3I_RS38530 8630901..8631173 - 273 WP_041563145.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(7-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12200.84 Da        Isoelectric Point: 6.4841

>T28377 WP_202805031.1 NC_018681:8628746-8629072 [Nocardia brasiliensis ATCC 700358]
MKLCESDPATAALVEQALDRLAAVGPALGRPLVDTLEHSRLRNLKELRPGSRGHSEIRILFVFDPDREAIILVAGDKAGR
WSHWYDDAIPLAEQRFADYRAQKHEENK

Download         Length: 327 bp

>T28377 NC_018681:8628746-8629072 [Nocardia brasiliensis ATCC 700358]
ATGAAGCTGTGCGAATCCGATCCGGCGACGGCCGCCTTGGTCGAGCAGGCGCTGGACCGACTAGCTGCCGTCGGTCCTGC
GCTCGGCAGACCCCTAGTCGACACCCTCGAGCACAGCCGGCTGCGCAATCTGAAGGAACTCAGACCTGGCTCCCGCGGAC
ACTCGGAAATACGCATCCTGTTCGTATTCGATCCGGACCGCGAAGCCATCATCCTGGTTGCGGGTGACAAGGCCGGACGG
TGGTCACACTGGTACGACGACGCGATCCCGTTGGCAGAGCAGCGCTTTGCCGACTATCGCGCCCAGAAGCACGAGGAGAA
CAAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11490.99 Da        Isoelectric Point: 7.0740

>AT28377 WP_041563143.1 NC_018681:8629069-8629398 [Nocardia brasiliensis ATCC 700358]
MSAARNWRDVKAEAHRLHPELAEPEAQAAAAAQLDAHIAGHHLKELRKAVGRTQAEIAAVLGVSQSRVSQIENGDLAAME
LDTLRAYAQALGGSVNITVSVGPHTVKVA

Download         Length: 330 bp

>AT28377 NC_018681:8629069-8629398 [Nocardia brasiliensis ATCC 700358]
ATGAGCGCTGCCCGAAACTGGCGAGATGTGAAGGCTGAAGCCCATCGCCTACATCCCGAACTGGCCGAACCAGAGGCCCA
GGCGGCCGCGGCCGCACAATTGGATGCTCACATTGCTGGTCACCACCTGAAGGAACTCCGTAAGGCCGTAGGAAGGACCC
AGGCCGAGATTGCGGCGGTTCTCGGTGTCTCGCAGTCCCGTGTCTCCCAGATCGAGAACGGCGATCTGGCTGCCATGGAA
CTCGACACCCTGCGCGCCTATGCGCAGGCGTTGGGCGGGAGCGTCAACATCACTGTGAGCGTCGGCCCGCACACCGTGAA
AGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References