Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 8346427..8347124 Replicon chromosome
Accession NC_018681
Organism Nocardia brasiliensis ATCC 700358

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag O3I_RS37320 Protein ID WP_202805028.1
Coordinates 8346427..8346810 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag O3I_RS37325 Protein ID WP_014988234.1
Coordinates 8346807..8347124 (+) Length 106 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3I_RS37300 8341771..8343588 - 1818 WP_042258020.1 EAL domain-containing protein -
O3I_RS37305 8344367..8344801 - 435 WP_014988230.1 effector binding domain-containing protein -
O3I_RS37310 8344836..8345279 - 444 WP_014988231.1 GyrI-like domain-containing protein -
O3I_RS37315 8345650..8346369 + 720 WP_014988232.1 uracil-DNA glycosylase -
O3I_RS37320 8346427..8346810 + 384 WP_202805028.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3I_RS37325 8346807..8347124 + 318 WP_014988234.1 helix-turn-helix domain-containing protein Antitoxin
O3I_RS37330 8347314..8348549 + 1236 WP_014988235.1 cation:proton antiporter -
O3I_RS37335 8348546..8349235 + 690 WP_081594232.1 HAD-IB family hydrolase -
O3I_RS37340 8349264..8350490 - 1227 WP_014988237.1 epoxide hydrolase -
O3I_RS37345 8350522..8350956 - 435 WP_014988238.1 MarR family transcriptional regulator -
O3I_RS37350 8351125..8352123 + 999 WP_014988239.1 membrane protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(22-113)

Antitoxin

(37-87)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14873.81 Da        Isoelectric Point: 4.8037

>T28376 WP_202805028.1 NC_018681:8346427-8346810 [Nocardia brasiliensis ATCC 700358]
IPILFEVTDSGWDIYVVDEVRDWITQLDEPDYSRVVHAIDILADYGPGLGRPLVDTLTGSKLPNLKELRTGTTRILFAFD
PWRSTVLLVAGDKDRQWRSWYRSAIPLAEHRYETYLKERREELENPR

Download         Length: 384 bp

>T28376 NC_018681:8346427-8346810 [Nocardia brasiliensis ATCC 700358]
ATTCCTATACTCTTCGAGGTGACAGACTCTGGTTGGGACATTTACGTGGTCGACGAGGTCCGCGATTGGATCACGCAGTT
GGACGAACCCGATTACAGCCGGGTGGTGCACGCCATCGACATCCTGGCCGACTACGGCCCCGGACTAGGGCGTCCGCTCG
TCGACACGTTAACGGGTTCGAAGCTGCCGAACCTGAAAGAACTTCGAACCGGCACTACCCGCATTCTGTTCGCCTTCGAC
CCTTGGCGATCGACCGTGCTCTTGGTCGCCGGGGACAAGGACCGCCAGTGGAGATCGTGGTATCGGTCGGCAATTCCGCT
GGCAGAACACCGCTATGAGACCTATCTGAAAGAGCGCCGAGAGGAATTGGAGAACCCGCGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11562.13 Da        Isoelectric Point: 8.5407

>AT28376 WP_014988234.1 NC_018681:8346807-8347124 [Nocardia brasiliensis ATCC 700358]
MTGYSRWQDIRAEFVERAGGEDAVAVGKEELLAEMIGHRLAEIRRSRGLTQQQIAARMGVTKGRISQIERGQIAGYELLA
RYATALGGRLRQSIQFDDGEVAAIA

Download         Length: 318 bp

>AT28376 NC_018681:8346807-8347124 [Nocardia brasiliensis ATCC 700358]
ATGACCGGATACTCACGCTGGCAAGACATCCGGGCCGAGTTCGTCGAACGAGCCGGCGGCGAAGACGCCGTCGCCGTCGG
CAAAGAGGAACTGCTCGCGGAGATGATCGGGCACCGACTGGCCGAGATCCGCCGCTCCCGCGGGTTGACACAGCAACAGA
TCGCGGCGCGGATGGGCGTCACCAAAGGACGGATCTCCCAGATCGAACGCGGACAGATCGCGGGCTACGAACTACTGGCC
CGATACGCCACGGCACTCGGCGGACGGCTGCGCCAGTCGATCCAGTTCGACGACGGTGAAGTGGCCGCCATCGCTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References