Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 8346427..8347124 | Replicon | chromosome |
Accession | NC_018681 | ||
Organism | Nocardia brasiliensis ATCC 700358 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | O3I_RS37320 | Protein ID | WP_202805028.1 |
Coordinates | 8346427..8346810 (+) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | O3I_RS37325 | Protein ID | WP_014988234.1 |
Coordinates | 8346807..8347124 (+) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
O3I_RS37300 | 8341771..8343588 | - | 1818 | WP_042258020.1 | EAL domain-containing protein | - |
O3I_RS37305 | 8344367..8344801 | - | 435 | WP_014988230.1 | effector binding domain-containing protein | - |
O3I_RS37310 | 8344836..8345279 | - | 444 | WP_014988231.1 | GyrI-like domain-containing protein | - |
O3I_RS37315 | 8345650..8346369 | + | 720 | WP_014988232.1 | uracil-DNA glycosylase | - |
O3I_RS37320 | 8346427..8346810 | + | 384 | WP_202805028.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
O3I_RS37325 | 8346807..8347124 | + | 318 | WP_014988234.1 | helix-turn-helix domain-containing protein | Antitoxin |
O3I_RS37330 | 8347314..8348549 | + | 1236 | WP_014988235.1 | cation:proton antiporter | - |
O3I_RS37335 | 8348546..8349235 | + | 690 | WP_081594232.1 | HAD-IB family hydrolase | - |
O3I_RS37340 | 8349264..8350490 | - | 1227 | WP_014988237.1 | epoxide hydrolase | - |
O3I_RS37345 | 8350522..8350956 | - | 435 | WP_014988238.1 | MarR family transcriptional regulator | - |
O3I_RS37350 | 8351125..8352123 | + | 999 | WP_014988239.1 | membrane protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14873.81 Da Isoelectric Point: 4.8037
>T28376 WP_202805028.1 NC_018681:8346427-8346810 [Nocardia brasiliensis ATCC 700358]
IPILFEVTDSGWDIYVVDEVRDWITQLDEPDYSRVVHAIDILADYGPGLGRPLVDTLTGSKLPNLKELRTGTTRILFAFD
PWRSTVLLVAGDKDRQWRSWYRSAIPLAEHRYETYLKERREELENPR
IPILFEVTDSGWDIYVVDEVRDWITQLDEPDYSRVVHAIDILADYGPGLGRPLVDTLTGSKLPNLKELRTGTTRILFAFD
PWRSTVLLVAGDKDRQWRSWYRSAIPLAEHRYETYLKERREELENPR
Download Length: 384 bp
>T28376 NC_018681:8346427-8346810 [Nocardia brasiliensis ATCC 700358]
ATTCCTATACTCTTCGAGGTGACAGACTCTGGTTGGGACATTTACGTGGTCGACGAGGTCCGCGATTGGATCACGCAGTT
GGACGAACCCGATTACAGCCGGGTGGTGCACGCCATCGACATCCTGGCCGACTACGGCCCCGGACTAGGGCGTCCGCTCG
TCGACACGTTAACGGGTTCGAAGCTGCCGAACCTGAAAGAACTTCGAACCGGCACTACCCGCATTCTGTTCGCCTTCGAC
CCTTGGCGATCGACCGTGCTCTTGGTCGCCGGGGACAAGGACCGCCAGTGGAGATCGTGGTATCGGTCGGCAATTCCGCT
GGCAGAACACCGCTATGAGACCTATCTGAAAGAGCGCCGAGAGGAATTGGAGAACCCGCGATGA
ATTCCTATACTCTTCGAGGTGACAGACTCTGGTTGGGACATTTACGTGGTCGACGAGGTCCGCGATTGGATCACGCAGTT
GGACGAACCCGATTACAGCCGGGTGGTGCACGCCATCGACATCCTGGCCGACTACGGCCCCGGACTAGGGCGTCCGCTCG
TCGACACGTTAACGGGTTCGAAGCTGCCGAACCTGAAAGAACTTCGAACCGGCACTACCCGCATTCTGTTCGCCTTCGAC
CCTTGGCGATCGACCGTGCTCTTGGTCGCCGGGGACAAGGACCGCCAGTGGAGATCGTGGTATCGGTCGGCAATTCCGCT
GGCAGAACACCGCTATGAGACCTATCTGAAAGAGCGCCGAGAGGAATTGGAGAACCCGCGATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11562.13 Da Isoelectric Point: 8.5407
>AT28376 WP_014988234.1 NC_018681:8346807-8347124 [Nocardia brasiliensis ATCC 700358]
MTGYSRWQDIRAEFVERAGGEDAVAVGKEELLAEMIGHRLAEIRRSRGLTQQQIAARMGVTKGRISQIERGQIAGYELLA
RYATALGGRLRQSIQFDDGEVAAIA
MTGYSRWQDIRAEFVERAGGEDAVAVGKEELLAEMIGHRLAEIRRSRGLTQQQIAARMGVTKGRISQIERGQIAGYELLA
RYATALGGRLRQSIQFDDGEVAAIA
Download Length: 318 bp
>AT28376 NC_018681:8346807-8347124 [Nocardia brasiliensis ATCC 700358]
ATGACCGGATACTCACGCTGGCAAGACATCCGGGCCGAGTTCGTCGAACGAGCCGGCGGCGAAGACGCCGTCGCCGTCGG
CAAAGAGGAACTGCTCGCGGAGATGATCGGGCACCGACTGGCCGAGATCCGCCGCTCCCGCGGGTTGACACAGCAACAGA
TCGCGGCGCGGATGGGCGTCACCAAAGGACGGATCTCCCAGATCGAACGCGGACAGATCGCGGGCTACGAACTACTGGCC
CGATACGCCACGGCACTCGGCGGACGGCTGCGCCAGTCGATCCAGTTCGACGACGGTGAAGTGGCCGCCATCGCTTGA
ATGACCGGATACTCACGCTGGCAAGACATCCGGGCCGAGTTCGTCGAACGAGCCGGCGGCGAAGACGCCGTCGCCGTCGG
CAAAGAGGAACTGCTCGCGGAGATGATCGGGCACCGACTGGCCGAGATCCGCCGCTCCCGCGGGTTGACACAGCAACAGA
TCGCGGCGCGGATGGGCGTCACCAAAGGACGGATCTCCCAGATCGAACGCGGACAGATCGCGGGCTACGAACTACTGGCC
CGATACGCCACGGCACTCGGCGGACGGCTGCGCCAGTCGATCCAGTTCGACGACGGTGAAGTGGCCGCCATCGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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