Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4640948..4641194 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag QQ972_RS22565 Protein ID WP_000956458.1
Coordinates 4640948..4641100 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 4641140..4641194 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS22550 4636775..4637683 - 909 WP_000372392.1 sulfate adenylyltransferase subunit CysD -
QQ972_RS22555 4637935..4638972 + 1038 WP_097738253.1 alkaline phosphatase isozyme conversion aminopeptidase -
QQ972_RS22560 4639089..4640753 - 1665 Protein_4404 CRISPR-associated helicase Cas3' -
QQ972_RS22565 4640948..4641100 - 153 WP_000956458.1 Hok/Gef family protein Toxin
- 4641140..4641194 + 55 - - Antitoxin
QQ972_RS22570 4641365..4642099 - 735 WP_000039862.1 phosphoadenosine phosphosulfate reductase -
QQ972_RS22575 4642173..4643885 - 1713 WP_001290708.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
QQ972_RS22580 4643885..4645684 - 1800 WP_000211914.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T283735 WP_000956458.1 NZ_CP127255:c4641100-4640948 [Escherichia coli]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 55 bp

>AT283735 NZ_CP127255:4641140-4641194 [Escherichia coli]
GTTTGGGTTCGAACGTAAGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References