Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1697949..1698207 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag QQ972_RS08155 Protein ID WP_000809168.1
Coordinates 1697949..1698101 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 1698150..1698207 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS08135 1693193..1693906 - 714 WP_001102393.1 acidic protein MsyB -
QQ972_RS08140 1693932..1694336 - 405 WP_097752027.1 DUF2541 family protein -
QQ972_RS08145 1694709..1696625 + 1917 WP_000516135.1 molecular chaperone DnaK -
QQ972_RS08150 1696714..1697844 + 1131 WP_001118464.1 molecular chaperone DnaJ -
QQ972_RS08155 1697949..1698101 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 1698150..1698207 + 58 - - Antitoxin
QQ972_RS08160 1698716..1699477 + 762 WP_001274832.1 outer membrane protein OmpK -
QQ972_RS08165 1699498..1700991 + 1494 WP_285984965.1 sulfatase-like hydrolase/transferase -
QQ972_RS08170 1701120..1702379 + 1260 WP_285984966.1 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T283720 WP_000809168.1 NZ_CP127255:c1698101-1697949 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT283720 NZ_CP127255:1698150-1698207 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References