Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 216863..217662 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag QQ972_RS01045 Protein ID WP_001592740.1
Coordinates 217198..217662 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QQ972_RS01040 Protein ID WP_001296435.1
Coordinates 216863..217198 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS01025 (212648) 212648..213418 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QQ972_RS01030 (213434) 213434..214768 - 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
QQ972_RS01035 (215143) 215143..216714 + 1572 WP_001273763.1 galactarate dehydratase -
QQ972_RS01040 (216863) 216863..217198 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QQ972_RS01045 (217198) 217198..217662 + 465 WP_001592740.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QQ972_RS01050 (217717) 217717..218526 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QQ972_RS01055 (218775) 218775..220055 + 1281 WP_000681941.1 tagatose-bisphosphate aldolase subunit KbaZ -
QQ972_RS01060 (220078) 220078..220551 + 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
QQ972_RS01065 (220562) 220562..221341 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QQ972_RS01070 (221331) 221331..222209 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QQ972_RS01075 (222227) 222227..222661 + 435 WP_000948834.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17776.15 Da        Isoelectric Point: 9.6927

>T283718 WP_001592740.1 NZ_CP127255:217198-217662 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KNWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT283718 WP_001296435.1 NZ_CP127255:216863-217198 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References