Detailed information of TA system TA283714

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 98217..98638
• Replicon: plasmid pC4101
• Accession: NZ_CP127254
• Organism: Escherichia coli strain C41

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QQ971_RS25150
• Protein ID: WP_096937776.1
• Coordinates: 98513..98638 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	98217..98415 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQ971_RS25120 (94147)	94147..94686	+	540	WP_000290801.1	single-stranded DNA-binding protein	-
QQ971_RS25125 (94743)	94743..94976	+	234	WP_000005990.1	DUF905 family protein	-
QQ971_RS25130 (95042)	95042..97000	+	1959	WP_000117171.1	ParB/RepB/Spo0J family partition protein	-
QQ971_RS25135 (97055)	97055..97489	+	435	WP_000845928.1	conjugation system SOS inhibitor PsiB	-
QQ971_RS25140 (97486)	97486..98248	+	763	Protein_90	plasmid SOS inhibition protein A	-
- (98217)	98217..98415	+	199	NuclAT_0	-	Antitoxin
- (98217)	98217..98415	+	199	NuclAT_0	-	Antitoxin
- (98217)	98217..98415	+	199	NuclAT_0	-	Antitoxin
- (98217)	98217..98415	+	199	NuclAT_0	-	Antitoxin
QQ971_RS25145 (98422)	98422..98571	+	150	Protein_91	DUF5431 family protein	-
QQ971_RS25150 (98513)	98513..98638	+	126	WP_096937776.1	type I toxin-antitoxin system Hok family toxin	Toxin
QQ971_RS25155 (98939)	98939..99235	-	297	Protein_93	hypothetical protein	-
QQ971_RS25160 (99305)	99305..99511	+	207	WP_000547963.1	hypothetical protein	-
QQ971_RS25165 (99536)	99536..99823	+	288	WP_000107542.1	hypothetical protein	-
QQ971_RS25170 (99942)	99942..100763	+	822	WP_001234474.1	DUF932 domain-containing protein	-
QQ971_RS25175 (101058)	101058..101660	-	603	WP_000243701.1	transglycosylase SLT domain-containing protein	-
QQ971_RS25180 (101981)	101981..102364	+	384	WP_001151524.1	conjugal transfer relaxosome DNA-binding protein TraM	-
QQ971_RS25185 (102551)	102551..103240	+	690	WP_285978676.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..114529	114529

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4806.72 Da
• Isoelectric Point: 8.4890

>T283714 WP_096937776.1 NZ_CP127254:98513-98638 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 199 bp

>AT283714 NZ_CP127254:98217-98415 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Structures

Antitoxin