Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4886735..4887534 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag QQ971_RS23860 Protein ID WP_000347266.1
Coordinates 4887070..4887534 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QQ971_RS23855 Protein ID WP_001307405.1
Coordinates 4886735..4887070 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS23840 (4882520) 4882520..4883290 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QQ971_RS23845 (4883306) 4883306..4884640 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QQ971_RS23850 (4885015) 4885015..4886586 + 1572 WP_001273741.1 galactarate dehydratase -
QQ971_RS23855 (4886735) 4886735..4887070 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QQ971_RS23860 (4887070) 4887070..4887534 + 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QQ971_RS23865 (4887589) 4887589..4888398 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QQ971_RS23870 (4888647) 4888647..4889927 + 1281 WP_097313944.1 tagatose-bisphosphate aldolase subunit KbaZ -
QQ971_RS23875 (4889950) 4889950..4890423 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QQ971_RS23880 (4890434) 4890434..4891213 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QQ971_RS23885 (4891203) 4891203..4892081 + 879 WP_115195113.1 PTS N-acetylgalactosamine transporter subunit IID -
QQ971_RS23890 (4892099) 4892099..4892533 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4876080..4887534 11454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T283710 WP_000347266.1 NZ_CP127252:4887070-4887534 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT283710 WP_001307405.1 NZ_CP127252:4886735-4887070 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References