Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3617433..3617935 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QQ971_RS17885 Protein ID WP_000767829.1
Coordinates 3617433..3617687 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QQ971_RS17890 Protein ID WP_001259255.1
Coordinates 3617684..3617935 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS17855 (3612449) 3612449..3612676 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
QQ971_RS17860 (3612690) 3612690..3613748 - 1059 WP_000492311.1 thiosulfate utilization transporter TsuA/YeeE -
QQ971_RS17865 (3613927) 3613927..3615285 - 1359 WP_024250698.1 putrescine/proton symporter PlaP -
QQ971_RS17870 (3615275) 3615275..3615337 - 63 WP_010723108.1 membrane protein YoeI -
QQ971_RS17875 (3615551) 3615551..3616480 - 930 WP_053292573.1 LysR substrate-binding domain-containing protein -
QQ971_RS17880 (3616526) 3616526..3617350 - 825 WP_000754737.1 SDR family oxidoreductase -
QQ971_RS17885 (3617433) 3617433..3617687 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QQ971_RS17890 (3617684) 3617684..3617935 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QQ971_RS17895 (3618218) 3618218..3618268 + 51 WP_001364200.1 his operon leader peptide -
QQ971_RS17900 (3618414) 3618414..3619313 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QQ971_RS17905 (3619319) 3619319..3620623 + 1305 WP_000009594.1 histidinol dehydrogenase -
QQ971_RS17910 (3620620) 3620620..3621690 + 1071 WP_286004723.1 histidinol-phosphate transaminase -
QQ971_RS17915 (3621690) 3621690..3622757 + 1068 WP_000080095.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T283705 WP_000767829.1 NZ_CP127252:c3617687-3617433 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT283705 WP_001259255.1 NZ_CP127252:c3617935-3617684 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References