Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1530316..1530857 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QQ971_RS07290 Protein ID WP_000615976.1
Coordinates 1530316..1530594 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QQ971_RS07295 Protein ID WP_000729704.1
Coordinates 1530597..1530857 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS07275 (1527898) 1527898..1528476 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
QQ971_RS07280 (1528682) 1528682..1529449 + 768 WP_000333380.1 class II glutamine amidotransferase -
QQ971_RS07285 (1529420) 1529420..1530160 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QQ971_RS07290 (1530316) 1530316..1530594 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QQ971_RS07295 (1530597) 1530597..1530857 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QQ971_RS07300 (1531043) 1531043..1531816 + 774 WP_000543899.1 C40 family peptidase -
QQ971_RS07305 (1531873) 1531873..1532229 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
QQ971_RS07310 (1532222) 1532222..1532500 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QQ971_RS07315 (1532605) 1532605..1534698 - 2094 Protein_1413 flagellar biosynthesis protein FlhA -
QQ971_RS07320 (1534682) 1534682..1535821 - 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T283690 WP_000615976.1 NZ_CP127252:c1530594-1530316 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT283690 WP_000729704.1 NZ_CP127252:c1530857-1530597 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References