Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 151904..152157 | Replicon | plasmid pKPC2_130119 |
Accession | NZ_CP127230 | ||
Organism | Klebsiella pneumoniae strain 130119 |
Toxin (Protein)
Gene name | srnB | Uniprot ID | G9G1E3 |
Locus tag | QRA14_RS27725 | Protein ID | WP_001312851.1 |
Coordinates | 152008..152157 (+) | Length | 50 a.a. |
Antitoxin (RNA)
Gene name | srnC | ||
Locus tag | - | ||
Coordinates | 151904..151963 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRA14_RS27685 (147564) | 147564..147629 | - | 66 | Protein_199 | helix-turn-helix domain-containing protein | - |
QRA14_RS27690 (147682) | 147682..148386 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
QRA14_RS27695 (148411) | 148411..148611 | + | 201 | WP_072354025.1 | hypothetical protein | - |
QRA14_RS27700 (148631) | 148631..149377 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
QRA14_RS27705 (149432) | 149432..149992 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
QRA14_RS27710 (150124) | 150124..150324 | + | 201 | WP_015059022.1 | hypothetical protein | - |
QRA14_RS27715 (150710) | 150710..151309 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
QRA14_RS27720 (151371) | 151371..151703 | + | 333 | WP_152916585.1 | hypothetical protein | - |
- (151904) | 151904..151963 | - | 60 | NuclAT_1 | - | Antitoxin |
- (151904) | 151904..151963 | - | 60 | NuclAT_1 | - | Antitoxin |
- (151904) | 151904..151963 | - | 60 | NuclAT_1 | - | Antitoxin |
- (151904) | 151904..151963 | - | 60 | NuclAT_1 | - | Antitoxin |
QRA14_RS27725 (152008) | 152008..152157 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
QRA14_RS27730 (152441) | 152441..152689 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB | - | 1..153000 | 153000 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T283650 WP_001312851.1 NZ_CP127230:152008-152157 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
Antitoxin
Download Length: 60 bp
>AT283650 NZ_CP127230:c151963-151904 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|