Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 2658422..2659068 | Replicon | chromosome |
Accession | NZ_CP127229 | ||
Organism | Klebsiella pneumoniae strain 130119 |
Toxin (Protein)
Gene name | higB | Uniprot ID | W8UNE1 |
Locus tag | QRA14_RS12765 | Protein ID | WP_002920560.1 |
Coordinates | 2658422..2658769 (+) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | W8UB68 |
Locus tag | QRA14_RS12770 | Protein ID | WP_002920557.1 |
Coordinates | 2658769..2659068 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRA14_RS12755 (QRA14_12755) | 2654348..2655781 | + | 1434 | WP_002920564.1 | glycogen synthase GlgA | - |
QRA14_RS12760 (QRA14_12760) | 2655799..2658246 | + | 2448 | WP_002920561.1 | glycogen phosphorylase | - |
QRA14_RS12765 (QRA14_12765) | 2658422..2658769 | + | 348 | WP_002920560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
QRA14_RS12770 (QRA14_12770) | 2658769..2659068 | + | 300 | WP_002920557.1 | helix-turn-helix transcriptional regulator | Antitoxin |
QRA14_RS12775 (QRA14_12775) | 2659131..2660639 | - | 1509 | WP_002920554.1 | glycerol-3-phosphate dehydrogenase | - |
QRA14_RS12780 (QRA14_12780) | 2660844..2661173 | + | 330 | WP_002920552.1 | thiosulfate sulfurtransferase GlpE | - |
QRA14_RS12785 (QRA14_12785) | 2661224..2662054 | + | 831 | WP_004151408.1 | rhomboid family intramembrane serine protease GlpG | - |
QRA14_RS12790 (QRA14_12790) | 2662104..2662862 | + | 759 | WP_002920548.1 | DeoR/GlpR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13502.56 Da Isoelectric Point: 6.2300
>T283639 WP_002920560.1 NZ_CP127229:2658422-2658769 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER
Download Length: 348 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E1CBY5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E1CBF8 |