Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2634734..2635070 Replicon chromosome
Accession NZ_CP127177
Organism Enterococcus faecalis strain 90_2023

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag QQS48_RS12525 Protein ID WP_002381035.1
Coordinates 2634734..2634877 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2635021..2635070 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQS48_RS12510 (2630450) 2630450..2631082 - 633 WP_002358972.1 RloB family protein -
QQS48_RS12515 (2631091) 2631091..2632386 - 1296 WP_002371641.1 ATP-binding protein -
QQS48_RS12520 (2632848) 2632848..2634464 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -
- (2634560) 2634560..2634623 - 64 NuclAT_5 - -
QQS48_RS12525 (2634734) 2634734..2634877 + 144 WP_002381035.1 putative holin-like toxin Toxin
- (2635021) 2635021..2635070 + 50 NuclAT_6 - Antitoxin
- (2634809) 2634809..2635071 - 263 NuclAT_4 - -
QQS48_RS12530 (2635072) 2635072..2638071 - 3000 WP_033786695.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T283617 WP_002381035.1 NZ_CP127177:2634734-2634877 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 50 bp

>AT283617 NZ_CP127177:2635021-2635070 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References