Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2421544..2421807 Replicon chromosome
Accession NZ_CP127024
Organism Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-048_8421A

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag QQO08_RS12285 Protein ID WP_001802298.1
Coordinates 2421703..2421807 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2421544..2421708 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO08_RS12260 (QQO08_12260) 2417727..2418392 - 666 WP_001024094.1 SDR family oxidoreductase -
QQO08_RS12265 (QQO08_12265) 2418544..2418864 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
QQO08_RS12270 (QQO08_12270) 2418866..2419846 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
QQO08_RS12275 (QQO08_12275) 2420112..2421203 + 1092 WP_000495671.1 lytic regulatory protein -
- 2421544..2421708 + 165 - - Antitoxin
QQO08_RS12285 (QQO08_12285) 2421703..2421807 - 105 WP_001802298.1 hypothetical protein Toxin
QQO08_RS12290 (QQO08_12290) 2421968..2422451 - 484 Protein_2386 recombinase family protein -
QQO08_RS12295 (QQO08_12295) 2422494..2423630 - 1137 WP_000115564.1 SAP domain-containing protein -
QQO08_RS12300 (QQO08_12300) 2423919..2424011 + 93 WP_001790138.1 hypothetical protein -
QQO08_RS12305 (QQO08_12305) 2424716..2425573 - 858 WP_000370924.1 HAD family hydrolase -
QQO08_RS12310 (QQO08_12310) 2425641..2426423 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T283541 WP_001802298.1 NZ_CP127024:c2421807-2421703 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

Antitoxin


Download         Length: 165 bp

>AT283541 NZ_CP127024:2421544-2421708 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References