Detailed information of TA system TA283532

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1662346..1662925
• Replicon: chromosome
• Accession: NZ_CP127024
• Organism: Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-048_8421A

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: QQO08_RS08175
• Protein ID: WP_001025401.1
• Coordinates: 1662680..1662925 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1662346..1662711 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQO08_RS08135 (QQO08_08135)	1659090..1659647	-	558	WP_000645045.1	DUF2815 family protein	-
QQO08_RS08140 (QQO08_08140)	1659673..1660839	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
QQO08_RS08145 (QQO08_08145)	1660836..1661198	-	363	WP_000985983.1	hypothetical protein	-
QQO08_RS08150 (QQO08_08150)	1661213..1661536	-	324	WP_000175000.1	hypothetical protein	-
QQO08_RS08155 (QQO08_08155)	1661615..1661776	-	162	WP_001285962.1	DUF1270 domain-containing protein	-
QQO08_RS08160 (QQO08_08160)	1661788..1662051	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
QQO08_RS08165 (QQO08_08165)	1662076..1662291	-	216	WP_001097555.1	hypothetical protein	-
QQO08_RS08170 (QQO08_08170)	1662346..1662711	+	366	WP_001128433.1	hypothetical protein	Antitoxin
QQO08_RS08175 (QQO08_08175)	1662680..1662925	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
QQO08_RS08180 (QQO08_08180)	1662981..1663190	+	210	WP_000642492.1	hypothetical protein	-
QQO08_RS08185 (QQO08_08185)	1663180..1663323	-	144	WP_000939498.1	hypothetical protein	-
QQO08_RS08190 (QQO08_08190)	1663352..1664128	-	777	WP_001148544.1	Rha family transcriptional regulator	-
QQO08_RS08195 (QQO08_08195)	1664142..1664378	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
QQO08_RS08200 (QQO08_08200)	1664530..1664844	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
QQO08_RS08205 (QQO08_08205)	1664857..1665318	+	462	WP_000525004.1	hypothetical protein	-
QQO08_RS08210 (QQO08_08210)	1665388..1665921	+	534	WP_251420282.1	gas vesicle protein GvpG	-
QQO08_RS08215 (QQO08_08215)	1666151..1666297	+	147	WP_001013104.1	hypothetical protein	-
QQO08_RS08220 (QQO08_08220)	1666294..1666908	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1622280..1680995	58715

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T283532 WP_001025401.1 NZ_CP127024:c1662925-1662680 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT283532 NZ_CP127024:1662346-1662711 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin