Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | sprA1-sprA1AS/- |
| Location | 1998821..1999003 | Replicon | chromosome |
| Accession | NZ_CP127021 | ||
| Organism | Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-021_7037M | ||
Toxin (Protein)
| Gene name | sprA1 | Uniprot ID | - |
| Locus tag | QQO10_RS09860 | Protein ID | WP_001801861.1 |
| Coordinates | 1998821..1998916 (+) | Length | 32 a.a. |
Antitoxin (RNA)
| Gene name | sprA1AS | ||
| Locus tag | - | ||
| Coordinates | 1998944..1999003 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQO10_RS09820 (QQO10_09820) | 1994481..1995107 | + | 627 | WP_000669046.1 | hypothetical protein | - |
| QQO10_RS09825 (QQO10_09825) | 1995148..1995492 | + | 345 | WP_000627551.1 | DUF3969 family protein | - |
| QQO10_RS09830 (QQO10_09830) | 1995590..1996141 | + | 552 | WP_000414205.1 | hypothetical protein | - |
| QQO10_RS09835 (QQO10_09835) | 1996359..1997000 | - | 642 | WP_000494956.1 | ImmA/IrrE family metallo-endopeptidase | - |
| QQO10_RS09840 (QQO10_09840) | 1997114..1997299 | - | 186 | WP_000809857.1 | hypothetical protein | - |
| QQO10_RS09845 (QQO10_09845) | 1997301..1997477 | - | 177 | WP_000375476.1 | hypothetical protein | - |
| QQO10_RS09850 (QQO10_09850) | 1997488..1997871 | - | 384 | WP_000070811.1 | hypothetical protein | - |
| QQO10_RS09855 (QQO10_09855) | 1998475..1998618 | - | 144 | WP_001549059.1 | transposase | - |
| QQO10_RS09860 (QQO10_09860) | 1998821..1998916 | + | 96 | WP_001801861.1 | type I toxin-antitoxin system Fst family toxin PepA1 | Toxin |
| - | 1998944..1999003 | - | 60 | - | - | Antitoxin |
| QQO10_RS09865 (QQO10_09865) | 1999039..1999140 | + | 102 | WP_001791893.1 | hypothetical protein | - |
| QQO10_RS09870 (QQO10_09870) | 1999118..1999294 | - | 177 | Protein_1947 | transposase | - |
| QQO10_RS09875 (QQO10_09875) | 1999488..1999865 | - | 378 | WP_001037045.1 | DUF1433 domain-containing protein | - |
| QQO10_RS09880 (QQO10_09880) | 2000386..2001654 | - | 1269 | Protein_1949 | ATP-binding protein | - |
| QQO10_RS09885 (QQO10_09885) | 2001706..2002877 | - | 1172 | Protein_1950 | IS256-like element IS256 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukD / hlgA | 1991921..2032172 | 40251 | |
| - | flank | IS/Tn | - | - | 2002011..2002877 | 866 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 32 a.a. Molecular weight: 3554.32 Da Isoelectric Point: 10.4449
>T283520 WP_001801861.1 NZ_CP127021:1998821-1998916 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
Download Length: 96 bp
Antitoxin
Download Length: 60 bp
>AT283520 NZ_CP127021:c1999003-1998944 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
