Detailed information of TA system TA283517

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1660891..1661470
• Replicon: chromosome
• Accession: NZ_CP127021
• Organism: Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-021_7037M

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: QQO10_RS08165
• Protein ID: WP_001025401.1
• Coordinates: 1661225..1661470 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1660891..1661256 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQO10_RS08125 (QQO10_08125)	1657635..1658192	-	558	WP_000645045.1	DUF2815 family protein	-
QQO10_RS08130 (QQO10_08130)	1658218..1659384	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
QQO10_RS08135 (QQO10_08135)	1659381..1659743	-	363	WP_000985983.1	hypothetical protein	-
QQO10_RS08140 (QQO10_08140)	1659758..1660081	-	324	WP_000175000.1	hypothetical protein	-
QQO10_RS08145 (QQO10_08145)	1660160..1660321	-	162	WP_001285962.1	DUF1270 domain-containing protein	-
QQO10_RS08150 (QQO10_08150)	1660333..1660596	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
QQO10_RS08155 (QQO10_08155)	1660621..1660836	-	216	WP_001097555.1	hypothetical protein	-
QQO10_RS08160 (QQO10_08160)	1660891..1661256	+	366	WP_001128433.1	hypothetical protein	Antitoxin
QQO10_RS08165 (QQO10_08165)	1661225..1661470	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
QQO10_RS08170 (QQO10_08170)	1661526..1661735	+	210	WP_000642492.1	hypothetical protein	-
QQO10_RS08175 (QQO10_08175)	1661725..1661868	-	144	WP_000939498.1	hypothetical protein	-
QQO10_RS08180 (QQO10_08180)	1661897..1662673	-	777	WP_001148544.1	Rha family transcriptional regulator	-
QQO10_RS08185 (QQO10_08185)	1662687..1662923	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
QQO10_RS08190 (QQO10_08190)	1663075..1663389	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
QQO10_RS08195 (QQO10_08195)	1663402..1663863	+	462	WP_000525004.1	hypothetical protein	-
QQO10_RS08200 (QQO10_08200)	1663933..1664466	+	534	WP_251420282.1	gas vesicle protein GvpG	-
QQO10_RS08205 (QQO10_08205)	1664696..1664842	+	147	WP_001013104.1	hypothetical protein	-
QQO10_RS08210 (QQO10_08210)	1664839..1665453	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1620827..1684415	63588

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T283517 WP_001025401.1 NZ_CP127021:c1661470-1661225 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT283517 NZ_CP127021:1660891-1661256 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin