Detailed information of TA system TA283497

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1665620..1666199
• Replicon: chromosome
• Accession: NZ_CP127019
• Organism: Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-009_371M

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: QQO11_RS08200
• Protein ID: WP_001025401.1
• Coordinates: 1665954..1666199 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1665620..1665985 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQO11_RS08160 (1662364)	1662364..1662921	-	558	WP_000645045.1	DUF2815 family protein	-
QQO11_RS08165 (1662947)	1662947..1664113	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
QQO11_RS08170 (1664110)	1664110..1664472	-	363	WP_000985983.1	hypothetical protein	-
QQO11_RS08175 (1664487)	1664487..1664810	-	324	WP_000175000.1	hypothetical protein	-
QQO11_RS08180 (1664889)	1664889..1665050	-	162	WP_001285962.1	DUF1270 domain-containing protein	-
QQO11_RS08185 (1665062)	1665062..1665325	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
QQO11_RS08190 (1665350)	1665350..1665565	-	216	WP_001097555.1	hypothetical protein	-
QQO11_RS08195 (1665620)	1665620..1665985	+	366	WP_001128433.1	hypothetical protein	Antitoxin
QQO11_RS08200 (1665954)	1665954..1666199	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
QQO11_RS08205 (1666255)	1666255..1666464	+	210	WP_000642492.1	hypothetical protein	-
QQO11_RS08210 (1666454)	1666454..1666597	-	144	WP_000939498.1	hypothetical protein	-
QQO11_RS08215 (1666626)	1666626..1667402	-	777	WP_001148544.1	Rha family transcriptional regulator	-
QQO11_RS08220 (1667416)	1667416..1667652	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
QQO11_RS08225 (1667804)	1667804..1668118	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
QQO11_RS08230 (1668131)	1668131..1668592	+	462	WP_000525004.1	hypothetical protein	-
QQO11_RS08235 (1668610)	1668610..1669194	+	585	WP_000825948.1	hypothetical protein	-
QQO11_RS08240 (1669424)	1669424..1669570	+	147	WP_001013104.1	hypothetical protein	-
QQO11_RS08245 (1669567)	1669567..1670181	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1625555..1689143	63588

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T283497 WP_001025401.1 NZ_CP127019:c1666199-1665954 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT283497 NZ_CP127019:1665620-1665985 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin