Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 9006722..9007310 Replicon chromosome
Accession NZ_CP126980
Organism Actinoplanes sp. NRRL 3884

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag Actob_RS40115 Protein ID WP_284917191.1
Coordinates 9007029..9007310 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Actob_RS40110 Protein ID WP_284917190.1
Coordinates 9006722..9007015 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Actob_RS40080 (ACTOB_008016) 9002067..9002813 - 747 WP_284917184.1 peptidase E -
Actob_RS40085 (ACTOB_008017) 9002810..9003643 - 834 WP_284917185.1 DNA polymerase subunit beta -
Actob_RS40090 (ACTOB_008018) 9003675..9004499 - 825 WP_284917186.1 G5 domain-containing protein -
Actob_RS40095 (ACTOB_008019) 9004709..9005173 + 465 WP_284917187.1 MarR family transcriptional regulator -
Actob_RS40100 (ACTOB_008020) 9005181..9005777 - 597 WP_284917188.1 phosphoesterase PA-phosphatase -
Actob_RS40105 (ACTOB_008021) 9005972..9006553 + 582 WP_284917189.1 Uma2 family endonuclease -
Actob_RS40110 (ACTOB_008022) 9006722..9007015 - 294 WP_284917190.1 HigA family addiction module antitoxin Antitoxin
Actob_RS40115 (ACTOB_008023) 9007029..9007310 - 282 WP_284917191.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Actob_RS40120 (ACTOB_008024) 9007464..9008549 - 1086 WP_284917192.1 redox-regulated ATPase YchF -
Actob_RS40125 (ACTOB_008025) 9008572..9009357 - 786 WP_284917193.1 alpha/beta hydrolase -
Actob_RS40130 (ACTOB_008026) 9009487..9010986 + 1500 WP_284917194.1 AlkA N-terminal domain-containing protein -
Actob_RS40135 (ACTOB_008027) 9011114..9011611 + 498 WP_284917195.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
Actob_RS40140 (ACTOB_008028) 9011554..9012276 - 723 WP_284917196.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10835.33 Da        Isoelectric Point: 8.0772

>T283447 WP_284917191.1 NZ_CP126980:c9007310-9007029 [Actinoplanes sp. NRRL 3884]
VIRSFGNRETERLWQREHVRSLDTRVLRTALRKLALLDAAMALADLRVPPGNRLEALSGDRKGQHSIRINDQWRICFVWT
ETGPEDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10876.52 Da        Isoelectric Point: 7.3183

>AT283447 WP_284917190.1 NZ_CP126980:c9007015-9006722 [Actinoplanes sp. NRRL 3884]
VTKLAPIHPGEVLMEDFITPLGITQHKVAVAIGVPPRRINEIVHGKRRISADTALRLSRYFGTTDLFWINLQNRYDLEVE
KDALGDSLDSIRPLQSA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References