Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 9006722..9007310 Replicon chromosome
Accession NZ_CP126980
Organism Actinoplanes sp. NRRL 3884

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag Actob_RS40115 Protein ID WP_284917191.1
Coordinates 9007029..9007310 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Actob_RS40110 Protein ID WP_284917190.1
Coordinates 9006722..9007015 (-) Length 98 a.a.

Genomic Context

Actob_RS40095Actob_RS40105Actob_RS40130Actob_RS40135Actob_RS40080Actob_RS40085Actob_RS40090Actob_RS40100Actob_RS40110Actob_RS40115Actob_RS40120Actob_RS40125Actob_RS40140
Location: 9004709..9005173 (465 bp)
Type: Others
Protein ID: WP_284917187.1
Location: 9005972..9006553 (582 bp)
Type: Others
Protein ID: WP_284917189.1
Location: 9009487..9010986 (1500 bp)
Type: Others
Protein ID: WP_284917194.1
Location: 9011114..9011611 (498 bp)
Type: Others
Protein ID: WP_284917195.1
Location: 9002067..9002813 (747 bp)
Type: Others
Protein ID: WP_284917184.1
Location: 9002810..9003643 (834 bp)
Type: Others
Protein ID: WP_284917185.1
Location: 9003675..9004499 (825 bp)
Type: Others
Protein ID: WP_284917186.1
Location: 9005181..9005777 (597 bp)
Type: Others
Protein ID: WP_284917188.1
Location: 9006722..9007015 (294 bp)
Type: Antitoxin
Protein ID: WP_284917190.1
Location: 9007029..9007310 (282 bp)
Type: Toxin
Protein ID: WP_284917191.1
Location: 9007464..9008549 (1086 bp)
Type: Others
Protein ID: WP_284917192.1
Location: 9008572..9009357 (786 bp)
Type: Others
Protein ID: WP_284917193.1
Location: 9011554..9012276 (723 bp)
Type: Others
Protein ID: WP_284917196.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Actob_RS40080 (ACTOB_008016)9002067..9002813-747WP_284917184.1peptidase E-
Actob_RS40085 (ACTOB_008017)9002810..9003643-834WP_284917185.1DNA polymerase subunit beta-
Actob_RS40090 (ACTOB_008018)9003675..9004499-825WP_284917186.1G5 domain-containing protein-
Actob_RS40095 (ACTOB_008019)9004709..9005173+465WP_284917187.1MarR family transcriptional regulator-
Actob_RS40100 (ACTOB_008020)9005181..9005777-597WP_284917188.1phosphoesterase PA-phosphatase-
Actob_RS40105 (ACTOB_008021)9005972..9006553+582WP_284917189.1Uma2 family endonuclease-
Actob_RS40110 (ACTOB_008022)9006722..9007015-294WP_284917190.1HigA family addiction module antitoxinAntitoxin
Actob_RS40115 (ACTOB_008023)9007029..9007310-282WP_284917191.1type II toxin-antitoxin system RelE/ParE family toxinToxin
Actob_RS40120 (ACTOB_008024)9007464..9008549-1086WP_284917192.1redox-regulated ATPase YchF-
Actob_RS40125 (ACTOB_008025)9008572..9009357-786WP_284917193.1alpha/beta hydrolase-
Actob_RS40130 (ACTOB_008026)9009487..9010986+1500WP_284917194.1AlkA N-terminal domain-containing protein-
Actob_RS40135 (ACTOB_008027)9011114..9011611+498WP_284917195.1methylated-DNA--[protein]-cysteine S-methyltransferase-
Actob_RS40140 (ACTOB_008028)9011554..9012276-723WP_284917196.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10835.33 Da        Isoelectric Point: 8.0772

>T283447 WP_284917191.1 NZ_CP126980:c9007310-9007029 [Actinoplanes sp. NRRL 3884]
VIRSFGNRETERLWQREHVRSLDTRVLRTALRKLALLDAAMALADLRVPPGNRLEALSGDRKGQHSIRINDQWRICFVWT
ETGPEDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10876.52 Da        Isoelectric Point: 7.3183

>AT283447 WP_284917190.1 NZ_CP126980:c9007015-9006722 [Actinoplanes sp. NRRL 3884]
VTKLAPIHPGEVLMEDFITPLGITQHKVAVAIGVPPRRINEIVHGKRRISADTALRLSRYFGTTDLFWINLQNRYDLEVE
KDALGDSLDSIRPLQSA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References