Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 8993664..8994370 Replicon chromosome
Accession NZ_CP126980
Organism Actinoplanes sp. NRRL 3884

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag Actob_RS40025 Protein ID WP_284917174.1
Coordinates 8993664..8994029 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Actob_RS40030 Protein ID WP_284922489.1
Coordinates 8994032..8994370 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Actob_RS40020 (ACTOB_008004) 8990948..8993542 - 2595 WP_284917173.1 LuxR C-terminal-related transcriptional regulator -
Actob_RS40025 (ACTOB_008005) 8993664..8994029 + 366 WP_284917174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Actob_RS40030 (ACTOB_008006) 8994032..8994370 + 339 WP_284922489.1 helix-turn-helix transcriptional regulator Antitoxin
Actob_RS40035 (ACTOB_008007) 8994444..8995532 - 1089 WP_284917175.1 alcohol dehydrogenase catalytic domain-containing protein -
Actob_RS40040 (ACTOB_008008) 8995529..8996938 - 1410 WP_284917176.1 aldehyde dehydrogenase family protein -
Actob_RS40045 (ACTOB_008009) 8996935..8997564 - 630 WP_284917177.1 TetR/AcrR family transcriptional regulator -
Actob_RS40050 (ACTOB_008010) 8997667..8999220 + 1554 WP_284917178.1 long-chain fatty acid--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-87)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13786.47 Da        Isoelectric Point: 5.2233

>T283446 WP_284917174.1 NZ_CP126980:8993664-8994029 [Actinoplanes sp. NRRL 3884]
VKEWEIFATDEFYAWADTLDRASLRHLVQAIDQLAEVGPGLGRPLVDHIEGSRVHNMKELRPGSSGRSEIRALFVFDPWR
STILLIGGDKSGNWSGWYRTAIPAAEELYARYLKDRQNEEA

Download         Length: 366 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12267.73 Da        Isoelectric Point: 7.2007

>AT283446 WP_284922489.1 NZ_CP126980:8994032-8994370 [Actinoplanes sp. NRRL 3884]
VPGYHKWSDIRAEFVEKAGGEEAIAEARRQSQAYVNGYRLAERRKSIGLTQAEVAERMGVTKGRVSQIERGEVATVDAIA
RYVHALGGYLQISAVFGDDQYILRGTDPQAAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References