Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 188835..189495 Replicon chromosome
Accession NZ_CP126978
Organism Gallibacterium anatis strain YJ922

Toxin (Protein)


Gene name higB Uniprot ID A0A0A3A103
Locus tag QP019_RS01160 Protein ID WP_052124504.1
Coordinates 189136..189495 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0A2ZWF9
Locus tag QP019_RS01155 Protein ID WP_039163779.1
Coordinates 188835..189134 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP019_RS01130 (QP019_01130) 184103..185176 + 1074 WP_285096430.1 DUF3383 family protein -
QP019_RS01135 (QP019_01135) 185228..185653 + 426 WP_264256125.1 DUF3277 family protein -
QP019_RS01140 (QP019_01140) 185653..186138 + 486 WP_285096431.1 hypothetical protein -
QP019_RS01145 (QP019_01145) 186174..186326 + 153 WP_017805951.1 hypothetical protein -
QP019_RS01150 (QP019_01150) 186323..188797 + 2475 WP_285096432.1 tape measure protein -
QP019_RS01155 (QP019_01155) 188835..189134 - 300 WP_039163779.1 helix-turn-helix transcriptional regulator Antitoxin
QP019_RS01160 (QP019_01160) 189136..189495 - 360 WP_052124504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP019_RS01165 (QP019_01165) 189561..190145 + 585 WP_285096433.1 hypothetical protein -
QP019_RS01170 (QP019_01170) 190231..191376 + 1146 WP_285096434.1 type I restriction endonuclease -
QP019_RS01175 (QP019_01175) 191460..191753 + 294 Protein_227 transposase -
QP019_RS01180 (QP019_01180) 191771..192796 + 1026 WP_285096435.1 IS3 family transposase -
QP019_RS01185 (QP019_01185) 192853..193626 - 774 WP_285096436.1 hypothetical protein -
QP019_RS01190 (QP019_01190) 193692..194024 + 333 WP_285096437.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 103046..245631 142585


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13592.72 Da        Isoelectric Point: 9.4530

>T283442 WP_052124504.1 NZ_CP126978:c189495-189136 [Gallibacterium anatis]
MAVNHQWNILFTDCFSKWLDQQDIPTKKSVAAALNLLKITGPELSRPYADTIKGSQYPNMKELRIQHQGKPLRAFFAFDP
LRQAIVLCAGDKSNDKQFYKRMIALADTEFAAYLANLEK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11321.03 Da        Isoelectric Point: 4.4463

>AT283442 WP_039163779.1 NZ_CP126978:c189134-188835 [Gallibacterium anatis]
MKTFDQFLDEFSPEDRKDIERMTDELLLESGLSLIRQEMEISQKQLADALGISQPAVAQIEQRGNDLRLSTLKRYVETMG
GKLSLAIDMPMGETRIFKI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A3A103

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2ZWF9

References