Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 139892..140552 Replicon chromosome
Accession NZ_CP126978
Organism Gallibacterium anatis strain YJ922

Toxin (Protein)


Gene name higB Uniprot ID A0A0A3A103
Locus tag QP019_RS00785 Protein ID WP_052124504.1
Coordinates 140193..140552 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0A2ZWF9
Locus tag QP019_RS00780 Protein ID WP_039163779.1
Coordinates 139892..140191 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP019_RS00755 (QP019_00755) 135160..136233 + 1074 WP_285096430.1 DUF3383 family protein -
QP019_RS00760 (QP019_00760) 136285..136710 + 426 WP_264256125.1 DUF3277 family protein -
QP019_RS00765 (QP019_00765) 136710..137195 + 486 WP_285096431.1 hypothetical protein -
QP019_RS00770 (QP019_00770) 137231..137383 + 153 WP_017805951.1 hypothetical protein -
QP019_RS00775 (QP019_00775) 137380..139854 + 2475 WP_285096432.1 tape measure protein -
QP019_RS00780 (QP019_00780) 139892..140191 - 300 WP_039163779.1 helix-turn-helix transcriptional regulator Antitoxin
QP019_RS00785 (QP019_00785) 140193..140552 - 360 WP_052124504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP019_RS00790 (QP019_00790) 140618..141202 + 585 WP_285096433.1 hypothetical protein -
QP019_RS00795 (QP019_00795) 141288..142433 + 1146 WP_285096434.1 type I restriction endonuclease -
QP019_RS00800 (QP019_00800) 142517..142810 + 294 Protein_152 transposase -
QP019_RS00805 (QP019_00805) 142828..143853 + 1026 WP_285096435.1 IS3 family transposase -
QP019_RS00810 (QP019_00810) 143910..144683 - 774 WP_285096436.1 hypothetical protein -
QP019_RS00815 (QP019_00815) 144749..145081 + 333 WP_285096437.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 103046..245631 142585


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13592.72 Da        Isoelectric Point: 9.4530

>T283440 WP_052124504.1 NZ_CP126978:c140552-140193 [Gallibacterium anatis]
MAVNHQWNILFTDCFSKWLDQQDIPTKKSVAAALNLLKITGPELSRPYADTIKGSQYPNMKELRIQHQGKPLRAFFAFDP
LRQAIVLCAGDKSNDKQFYKRMIALADTEFAAYLANLEK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11321.03 Da        Isoelectric Point: 4.4463

>AT283440 WP_039163779.1 NZ_CP126978:c140191-139892 [Gallibacterium anatis]
MKTFDQFLDEFSPEDRKDIERMTDELLLESGLSLIRQEMEISQKQLADALGISQPAVAQIEQRGNDLRLSTLKRYVETMG
GKLSLAIDMPMGETRIFKI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A3A103

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2ZWF9

References