Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 347793..348439 Replicon chromosome
Accession NZ_CP126974
Organism Klebsiella pneumoniae subsp. pneumoniae strain 111-2

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag QPX97_RS01605 Protein ID WP_016529833.1
Coordinates 347793..348140 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag QPX97_RS01610 Protein ID WP_002920557.1
Coordinates 348140..348439 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPX97_RS01595 (QPX97_01595) 343719..345152 + 1434 WP_130974867.1 glycogen synthase GlgA -
QPX97_RS01600 (QPX97_01600) 345170..347617 + 2448 WP_021312822.1 glycogen phosphorylase -
QPX97_RS01605 (QPX97_01605) 347793..348140 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QPX97_RS01610 (QPX97_01610) 348140..348439 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
QPX97_RS01615 (QPX97_01615) 348502..350010 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
QPX97_RS01620 (QPX97_01620) 350215..350544 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
QPX97_RS01625 (QPX97_01625) 350595..351425 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
QPX97_RS01630 (QPX97_01630) 351475..352233 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T283418 WP_016529833.1 NZ_CP126974:347793-348140 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT283418 WP_002920557.1 NZ_CP126974:348140-348439 [Klebsiella pneumoniae subsp. pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References