Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1729963..1730551 Replicon chromosome
Accession NZ_CP126970
Organism Corynebacterium sp. LM112

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QP029_RS08685 Protein ID WP_284873942.1
Coordinates 1729963..1730244 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QP029_RS08690 Protein ID WP_284873943.1
Coordinates 1730255..1730551 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP029_RS08670 (QP029_08670) 1726869..1727597 + 729 WP_284873939.1 hypothetical protein -
QP029_RS08675 (QP029_08675) 1727639..1729150 + 1512 WP_284873940.1 murein biosynthesis integral membrane protein MurJ -
QP029_RS08680 (QP029_08680) 1729246..1729686 + 441 WP_284873941.1 YtoQ family protein -
QP029_RS08685 (QP029_08685) 1729963..1730244 + 282 WP_284873942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP029_RS08690 (QP029_08690) 1730255..1730551 + 297 WP_284873943.1 HigA family addiction module antitoxin Antitoxin
QP029_RS08695 (QP029_08695) 1730669..1730974 + 306 WP_284873944.1 antibiotic biosynthesis monooxygenase family protein -
QP029_RS08700 (QP029_08700) 1730984..1731256 + 273 Protein_1694 2'-5' RNA ligase -
QP029_RS08705 (QP029_08705) 1731430..1732896 + 1467 WP_284876203.1 IS1634 family transposase -
QP029_RS08710 (QP029_08710) 1732926..1733363 + 438 Protein_1696 2'-5' RNA ligase -
QP029_RS08715 (QP029_08715) 1733392..1733649 - 258 WP_284873945.1 Txe/YoeB family addiction module toxin -
QP029_RS08720 (QP029_08720) 1733654..1733911 - 258 WP_284873946.1 type II toxin-antitoxin system prevent-host-death family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10890.72 Da        Isoelectric Point: 10.4396

>T283414 WP_284873942.1 NZ_CP126970:1729963-1730244 [Corynebacterium sp. LM112]
VIVSFADRDAERLFLRKRVRRLDPRVHRKALMKLLLLDAVHELGELRIPPGNRLEALKGDRIGQHSIRINDQWRICFVWT
VAGPSEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11077.67 Da        Isoelectric Point: 5.0944

>AT283414 WP_284873943.1 NZ_CP126970:1730255-1730551 [Corynebacterium sp. LM112]
MDDKIPPIHPGEILMEEFLGPMGVTQHRLAVSIGVPPRRINEIVHGKRRITADTALRLGRYFGMSAQFWINLQSHYDLEV
ERDALGDTLDDIEPLQSA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References