Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1842399..1842898 Replicon chromosome
Accession NZ_CP126958
Organism Aerococcus sp. UMB0080

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2I1L774
Locus tag CJ190_RS08355 Protein ID WP_070598384.1
Coordinates 1842399..1842653 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2I1L770
Locus tag CJ190_RS08360 Protein ID WP_070598386.1
Coordinates 1842653..1842898 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ190_RS08345 (CJ190_008345) 1837962..1841003 - 3042 WP_070598407.1 type I restriction endonuclease subunit R -
CJ190_RS08350 (CJ190_008350) 1841220..1842347 + 1128 WP_070598382.1 restriction endonuclease subunit S -
CJ190_RS08355 (CJ190_008355) 1842399..1842653 - 255 WP_070598384.1 Txe/YoeB family addiction module toxin Toxin
CJ190_RS08360 (CJ190_008360) 1842653..1842898 - 246 WP_070598386.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CJ190_RS08365 (CJ190_008365) 1842953..1843873 - 921 WP_070598388.1 site-specific integrase -
CJ190_RS08370 (CJ190_008370) 1844165..1844440 + 276 WP_070598390.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CJ190_RS08375 (CJ190_008375) 1844440..1844718 + 279 WP_070598393.1 type II toxin-antitoxin system YafQ family toxin -
CJ190_RS08380 (CJ190_008380) 1844958..1845578 - 621 WP_070598395.1 restriction endonuclease subunit S -
CJ190_RS08385 (CJ190_008385) 1845578..1846489 - 912 Protein_1600 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(A) - 1803030..1940282 137252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(13-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10350.82 Da        Isoelectric Point: 9.7495

>T283403 WP_070598384.1 NZ_CP126958:c1842653-1842399 [Aerococcus sp. UMB0080]
MKVHWSRRSVIEREAWRENDQKVYDKIYRLLRAIKEDPYQGLGKPEPLKYDLSGYWSRRLTRQDRLVYRVTDDAIEVLSC
KYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9568.43 Da        Isoelectric Point: 3.9325

>AT283403 WP_070598386.1 NZ_CP126958:c1842898-1842653 [Aerococcus sp. UMB0080]
MEVTNYSDFRQNMKHYMDQINEDAIEYTVTSQNGNDVVVMAKSDFDSLMETYHLLSSRANRENLYQAMDELDRGDYEVEE
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I1L774

Antitoxin

Source ID Structure
AlphaFold DB A0A2I1L770

References