Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3982003..3982802 Replicon chromosome
Accession NZ_CP126955
Organism Escherichia coli O78:H4 strain APEC E123

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QQA21_RS19595 Protein ID WP_000347251.1
Coordinates 3982338..3982802 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QQA21_RS19590 Protein ID WP_001307405.1
Coordinates 3982003..3982338 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA21_RS19575 (3977788) 3977788..3978558 - 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -
QQA21_RS19580 (3978574) 3978574..3979908 - 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
QQA21_RS19585 (3980283) 3980283..3981854 + 1572 WP_001273761.1 galactarate dehydratase -
QQA21_RS19590 (3982003) 3982003..3982338 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QQA21_RS19595 (3982338) 3982338..3982802 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QQA21_RS19600 (3982856) 3982856..3983665 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QQA21_RS19605 (3983914) 3983914..3985194 + 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
QQA21_RS19610 (3985217) 3985217..3985690 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QQA21_RS19615 (3985701) 3985701..3986480 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QQA21_RS19620 (3986470) 3986470..3987348 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QQA21_RS19625 (3987366) 3987366..3987800 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3971128..3982802 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T283391 WP_000347251.1 NZ_CP126955:3982338-3982802 [Escherichia coli O78:H4]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT283391 WP_001307405.1 NZ_CP126955:3982003-3982338 [Escherichia coli O78:H4]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References