Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 140319..140588 Replicon plasmid pEND_Eco 12049-1
Accession NZ_CP126953
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag QQA22_RS25860 Protein ID WP_001372321.1
Coordinates 140463..140588 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 140319..140384 (-)

Genomic Context


QQA22_RS25820QQA22_RS25825QQA22_RS25830QQA22_RS25835QQA22_RS25840QQA22_RS25845----QQA22_RS25855QQA22_RS25860QQA22_RS25865QQA22_RS25875QQA22_RS25880QQA22_RS25885QQA22_RS25895QQA22_RS25900QQA22_RS25850--QQA22_RS25870QQA22_RS25890
Location: 135361..135639 (279 bp)
Type: Others
Protein ID: WP_072127934.1
Location: 136112..136639 (528 bp)
Type: Others
Protein ID: WP_000290793.1
Location: 136695..136928 (234 bp)
Type: Others
Protein ID: WP_000006004.1
Location: 136987..138945 (1959 bp)
Type: Others
Protein ID: WP_001145469.1
Location: 139000..139434 (435 bp)
Type: Others
Protein ID: WP_000845895.1
Location: 139431..140193 (763 bp)
Type: Others
Protein ID: Protein_137
Location: 140162..140386 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 140162..140386 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 140162..140386 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 140162..140386 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 140372..140521 (150 bp)
Type: Others
Protein ID: Protein_139
Location: 140463..140588 (126 bp)
Type: Toxin
Protein ID: WP_001372321.1
Location: 140808..141038 (231 bp)
Type: Others
Protein ID: WP_001426396.1
Location: 141279..141485 (207 bp)
Type: Others
Protein ID: WP_000547939.1
Location: 141510..141797 (288 bp)
Type: Others
Protein ID: WP_000107535.1
Location: 141918..142739 (822 bp)
Type: Others
Protein ID: WP_001234469.1
Location: 143959..144342 (384 bp)
Type: Others
Protein ID: WP_001151524.1
Location: 144529..145218 (690 bp)
Type: Others
Protein ID: WP_000283385.1
Location: 140162..140350 (189 bp)
Type: Others
Protein ID: WP_001299721.1
Location: 140319..140384 (66 bp)
Type: Antitoxin
Protein ID: -
Location: 141036..141209 (174 bp)
Type: Others
Protein ID: Protein_142
Location: 143036..143638 (603 bp)
Type: Others
Protein ID: WP_000243709.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QQA22_RS25820135361..135639+279WP_072127934.1hypothetical protein-
QQA22_RS25825136112..136639+528WP_000290793.1single-stranded DNA-binding protein-
QQA22_RS25830136695..136928+234WP_000006004.1DUF905 domain-containing protein-
QQA22_RS25835136987..138945+1959WP_001145469.1ParB/RepB/Spo0J family partition protein-
QQA22_RS25840139000..139434+435WP_000845895.1conjugation system SOS inhibitor PsiB-
QQA22_RS25845139431..140193+763Protein_137plasmid SOS inhibition protein A-
QQA22_RS25850140162..140350-189WP_001299721.1hypothetical protein-
-140162..140386+225NuclAT_0--
-140162..140386+225NuclAT_0--
-140162..140386+225NuclAT_0--
-140162..140386+225NuclAT_0--
-140319..140384-66--Antitoxin
QQA22_RS25855140372..140521+150Protein_139plasmid maintenance protein Mok-
QQA22_RS25860140463..140588+126WP_001372321.1type I toxin-antitoxin system Hok family toxinToxin
QQA22_RS25865140808..141038+231WP_001426396.1hypothetical protein-
QQA22_RS25870141036..141209-174Protein_142hypothetical protein-
QQA22_RS25875141279..141485+207WP_000547939.1hypothetical protein-
QQA22_RS25880141510..141797+288WP_000107535.1hypothetical protein-
QQA22_RS25885141918..142739+822WP_001234469.1DUF932 domain-containing protein-
QQA22_RS25890143036..143638-603WP_000243709.1transglycosylase SLT domain-containing protein-
QQA22_RS25895143959..144342+384WP_001151524.1conjugal transfer relaxosome DNA-binding protein TraM-
QQA22_RS25900144529..145218+690WP_000283385.1conjugal transfer transcriptional regulator TraJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidsitABCDvat / iroB / iroC / iroD / iroE / iroN / iucA / iucB / iucC / iucD / iutA1..155857155857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T283367 WP_001372321.1 NZ_CP126953:140463-140588 [Escherichia coli O78:H4]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp


Antitoxin


Download         Length: 66 bp

>AT283367 NZ_CP126953:c140384-140319 [Escherichia coli O78:H4]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

Download structure file

References