Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4949928..4950530 Replicon chromosome
Accession NZ_CP126952
Organism Escherichia coli O78:H4 strain APEC E12049

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QQA22_RS24115 Protein ID WP_000897305.1
Coordinates 4950219..4950530 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA22_RS24110 Protein ID WP_000356397.1
Coordinates 4949928..4950218 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA22_RS24090 (4946430) 4946430..4947332 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA22_RS24095 (4947329) 4947329..4947964 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA22_RS24100 (4947961) 4947961..4948890 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QQA22_RS24105 (4949105) 4949105..4949323 - 219 WP_001295676.1 CopG family transcriptional regulator -
QQA22_RS24110 (4949928) 4949928..4950218 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA22_RS24115 (4950219) 4950219..4950530 - 312 WP_000897305.1 hypothetical protein Toxin
QQA22_RS24120 (4950759) 4950759..4951667 + 909 WP_001318161.1 alpha/beta hydrolase -
QQA22_RS24125 (4951731) 4951731..4952672 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA22_RS24130 (4952717) 4952717..4953154 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA22_RS24135 (4953151) 4953151..4954023 - 873 WP_000920762.1 virulence factor BrkB family protein -
QQA22_RS24140 (4954017) 4954017..4954616 - 600 WP_001315111.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T283358 WP_000897305.1 NZ_CP126952:c4950530-4950219 [Escherichia coli O78:H4]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283358 WP_000356397.1 NZ_CP126952:c4950218-4949928 [Escherichia coli O78:H4]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References