Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4800919..4801521 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QQA23_RS23375 Protein ID WP_000897305.1
Coordinates 4801210..4801521 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA23_RS23370 Protein ID WP_000356397.1
Coordinates 4800919..4801209 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS23350 (4797421) 4797421..4798323 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA23_RS23355 (4798320) 4798320..4798955 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA23_RS23360 (4798952) 4798952..4799881 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QQA23_RS23365 (4800096) 4800096..4800314 - 219 WP_001295676.1 CopG family transcriptional regulator -
QQA23_RS23370 (4800919) 4800919..4801209 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA23_RS23375 (4801210) 4801210..4801521 - 312 WP_000897305.1 hypothetical protein Toxin
QQA23_RS23380 (4801750) 4801750..4802658 + 909 WP_001318161.1 alpha/beta hydrolase -
QQA23_RS23385 (4802722) 4802722..4803663 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA23_RS23390 (4803708) 4803708..4804145 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA23_RS23395 (4804142) 4804142..4805014 - 873 WP_000920762.1 virulence factor BrkB family protein -
QQA23_RS23400 (4805008) 4805008..4805607 - 600 WP_001315111.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T283326 WP_000897305.1 NZ_CP126948:c4801521-4801210 [Escherichia coli O78:H4]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283326 WP_000356397.1 NZ_CP126948:c4801209-4800919 [Escherichia coli O78:H4]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References