Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 600150..600949 Replicon chromosome
Accession NZ_CP126948
Organism Escherichia coli O78:H4 strain APEC E14033

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QQA23_RS02960 Protein ID WP_000347251.1
Coordinates 600150..600614 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QQA23_RS02965 Protein ID WP_001296435.1
Coordinates 600614..600949 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA23_RS02930 (595151) 595151..595585 - 435 WP_000948823.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QQA23_RS02935 (595603) 595603..596481 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QQA23_RS02940 (596471) 596471..597250 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QQA23_RS02945 (597261) 597261..597734 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QQA23_RS02950 (597757) 597757..599037 - 1281 WP_000681938.1 tagatose-bisphosphate aldolase subunit KbaZ -
QQA23_RS02955 (599286) 599286..600095 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QQA23_RS02960 (600150) 600150..600614 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QQA23_RS02965 (600614) 600614..600949 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QQA23_RS02970 (601098) 601098..602669 - 1572 WP_001273941.1 galactarate dehydratase -
QQA23_RS02975 (603044) 603044..604378 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
QQA23_RS02980 (604394) 604394..605164 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T283307 WP_000347251.1 NZ_CP126948:c600614-600150 [Escherichia coli O78:H4]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT283307 WP_001296435.1 NZ_CP126948:c600949-600614 [Escherichia coli O78:H4]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References