Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 79712..79976 Replicon plasmid pESBL-EA11
Accession NC_018659
Organism Escherichia coli O104:H4 str. 2011C-3493

Toxin (Protein)


Gene name pndA Uniprot ID U9Z417
Locus tag O3K_RS26055 Protein ID WP_001387489.1
Coordinates 79824..79976 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 79712..79774 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3K_RS26040 75814..76884 - 1071 WP_000151588.1 IncI1-type conjugal transfer protein TrbB -
O3K_RS26045 76903..78111 - 1209 WP_000121263.1 IncI1-type conjugal transfer protein TrbA -
O3K_RS26050 78418..79509 - 1092 WP_000426061.1 hypothetical protein -
- 79712..79774 - 63 NuclAT_0 - Antitoxin
- 79712..79774 - 63 NuclAT_0 - Antitoxin
- 79712..79774 - 63 NuclAT_0 - Antitoxin
- 79712..79774 - 63 NuclAT_0 - Antitoxin
O3K_RS26055 79824..79976 + 153 WP_001387489.1 Hok/Gef family protein Toxin
O3K_RS26060 80048..80299 - 252 WP_001291964.1 hypothetical protein -
O3K_RS26065 80599..80895 + 297 WP_001275298.1 hypothetical protein -
O3K_RS26625 80960..81136 - 177 WP_001054898.1 hypothetical protein -
O3K_RS26070 81319..81528 - 210 WP_001140543.1 hemolysin expression modulator Hha -
O3K_RS26075 81626..82240 - 615 WP_000578648.1 plasmid IncI1-type surface exclusion protein ExcA -
O3K_RS26080 82316..84484 - 2169 WP_000698360.1 IncI1-type conjugal transfer membrane protein TraY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1B - 1..88544 88544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5761.10 Da        Isoelectric Point: 8.7948

>T28330 WP_001387489.1 NC_018659:79824-79976 [Escherichia coli O104:H4 str. 2011C-3493]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T28330 NC_018659:79824-79976 [Escherichia coli O104:H4 str. 2011C-3493]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT28330 NC_018659:c79774-79712 [Escherichia coli O104:H4 str. 2011C-3493]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z417

Antitoxin

Download structure file

References