Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4907150..4907752 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QQA24_RS23825 Protein ID WP_000897305.1
Coordinates 4907150..4907461 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA24_RS23830 Protein ID WP_000356397.1
Coordinates 4907462..4907752 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS23795 (4902180) 4902180..4902965 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
QQA24_RS23800 (4903064) 4903064..4903663 + 600 WP_001295269.1 glucose-1-phosphatase -
QQA24_RS23805 (4903657) 4903657..4904529 + 873 WP_000920762.1 virulence factor BrkB family protein -
QQA24_RS23810 (4904526) 4904526..4904963 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA24_RS23815 (4905008) 4905008..4905949 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA24_RS23820 (4906013) 4906013..4906921 - 909 WP_001162704.1 alpha/beta hydrolase -
QQA24_RS23825 (4907150) 4907150..4907461 + 312 WP_000897305.1 hypothetical protein Toxin
QQA24_RS23830 (4907462) 4907462..4907752 + 291 WP_000356397.1 NadS family protein Antitoxin
QQA24_RS23835 (4908357) 4908357..4908575 + 219 WP_001315930.1 CopG family transcriptional regulator -
QQA24_RS23840 (4908795) 4908795..4909037 + 243 WP_001087409.1 protein YiiF -
QQA24_RS23845 (4909367) 4909367..4910296 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QQA24_RS23850 (4910293) 4910293..4910928 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA24_RS23855 (4910925) 4910925..4911827 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T283292 WP_000897305.1 NZ_CP126946:4907150-4907461 [Escherichia coli O78:H51]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283292 WP_000356397.1 NZ_CP126946:4907462-4907752 [Escherichia coli O78:H51]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References