Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 769728..770269 Replicon chromosome
Accession NZ_CP126946
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QQA24_RS03695 Protein ID WP_000615976.1
Coordinates 769728..770006 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QQA24_RS03700 Protein ID WP_000729704.1
Coordinates 770009..770269 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS03680 (767310) 767310..767888 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
QQA24_RS03685 (768094) 768094..768861 + 768 WP_000333380.1 class II glutamine amidotransferase -
QQA24_RS03690 (768832) 768832..769572 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QQA24_RS03695 (769728) 769728..770006 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QQA24_RS03700 (770009) 770009..770269 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QQA24_RS03705 (770455) 770455..771228 + 774 WP_148935748.1 C40 family peptidase -
QQA24_RS03710 (771285) 771285..771641 - 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
QQA24_RS03715 (771634) 771634..771912 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QQA24_RS03720 (772017) 772017..773729 - 1713 Protein_730 flagellar biosynthesis protein FlhA -
QQA24_RS03725 (773701) 773701..774486 + 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 760779..771912 11133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T283268 WP_000615976.1 NZ_CP126946:c770006-769728 [Escherichia coli O78:H51]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT283268 WP_000729704.1 NZ_CP126946:c770269-770009 [Escherichia coli O78:H51]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References