283256

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4932618..4933220 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QQA28_RS24305 Protein ID WP_000897302.1
Coordinates 4932909..4933220 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA28_RS24300 Protein ID WP_000356397.1
Coordinates 4932618..4932908 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS24275 (4928691) 4928691..4929593 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA28_RS24280 (4929590) 4929590..4930225 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA28_RS24285 (4930222) 4930222..4931151 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QQA28_RS24290 (4931367) 4931367..4931585 - 219 WP_001314326.1 CopG family transcriptional regulator -
QQA28_RS24295 (4931981) 4931981..4932259 - 279 WP_001296612.1 hypothetical protein -
QQA28_RS24300 (4932618) 4932618..4932908 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA28_RS24305 (4932909) 4932909..4933220 - 312 WP_000897302.1 hypothetical protein Toxin
QQA28_RS24310 (4933449) 4933449..4934357 + 909 WP_001331553.1 alpha/beta hydrolase -
QQA28_RS24315 (4934421) 4934421..4935362 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA28_RS24320 (4935407) 4935407..4935844 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA28_RS24325 (4935841) 4935841..4936713 - 873 WP_000920754.1 virulence factor BrkB family protein -
QQA28_RS24330 (4936707) 4936707..4937306 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T283256 WP_000897302.1 NZ_CP126944:c4933220-4932909 [Escherichia coli O1:K1:H7]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283256 WP_000356397.1 NZ_CP126944:c4932908-4932618 [Escherichia coli O1:K1:H7]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References