Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3664101..3664780 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name higB Uniprot ID V0VBP6
Locus tag QQA28_RS18240 Protein ID WP_000057524.1
Coordinates 3664478..3664780 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag QQA28_RS18235 Protein ID WP_000806442.1
Coordinates 3664101..3664442 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS18225 (3660345) 3660345..3661277 - 933 WP_000883052.1 glutaminase A -
QQA28_RS18230 (3661539) 3661539..3664043 + 2505 WP_000083945.1 copper-exporting P-type ATPase CopA -
QQA28_RS18235 (3664101) 3664101..3664442 - 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
QQA28_RS18240 (3664478) 3664478..3664780 - 303 WP_000057524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQA28_RS18245 (3664913) 3664913..3665707 + 795 WP_000365177.1 TraB/GumN family protein -
QQA28_RS18250 (3665911) 3665911..3666390 + 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
QQA28_RS18255 (3666414) 3666414..3667214 + 801 WP_000439796.1 hypothetical protein -
QQA28_RS18260 (3667211) 3667211..3667714 + 504 WP_000667000.1 hypothetical protein -
QQA28_RS18265 (3667752) 3667752..3669404 - 1653 WP_080282699.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3656790..3667714 10924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11839.47 Da        Isoelectric Point: 10.2237

>T283245 WP_000057524.1 NZ_CP126944:c3664780-3664478 [Escherichia coli O1:K1:H7]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHWDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT283245 WP_000806442.1 NZ_CP126944:c3664442-3664101 [Escherichia coli O1:K1:H7]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0VBP6

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References