283244

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2620416..2620978 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag QQA28_RS12890 Protein ID WP_000605675.1
Coordinates 2620416..2620694 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag QQA28_RS12895 Protein ID WP_000781370.1
Coordinates 2620694..2620978 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS12865 (2616004) 2616004..2616435 - 432 WP_000152310.1 peroxiredoxin OsmC -
QQA28_RS12870 (2616780) 2616780..2616995 + 216 WP_000495766.1 biofilm-dependent modulation protein -
QQA28_RS12875 (2617097) 2617097..2617234 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
QQA28_RS12880 (2617390) 2617390..2619087 + 1698 WP_000433462.1 malate dehydrogenase -
QQA28_RS12885 (2619220) 2619220..2620230 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
QQA28_RS12890 (2620416) 2620416..2620694 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQA28_RS12895 (2620694) 2620694..2620978 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
QQA28_RS12900 (2621207) 2621207..2621860 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
QQA28_RS12905 (2621853) 2621853..2622737 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
QQA28_RS12910 (2622750) 2622750..2625797 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T283244 WP_000605675.1 NZ_CP126944:2620416-2620694 [Escherichia coli O1:K1:H7]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT283244 WP_000781370.1 NZ_CP126944:2620694-2620978 [Escherichia coli O1:K1:H7]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References