Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 66380..66805 | Replicon | plasmid pEND_Eco 18006 |
| Accession | NZ_CP126943 | ||
| Organism | Escherichia coli O1:K1:H7 strain APEC E18006 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | QQA29_RS25875 | Protein ID | WP_223195199.1 |
| Coordinates | 66380..66502 (-) | Length | 41 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 66594..66805 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQA29_RS25840 (61730) | 61730..61957 | - | 228 | WP_001442099.1 | conjugal transfer relaxosome protein TraY | - |
| QQA29_RS25845 (62051) | 62051..62737 | - | 687 | WP_289251617.1 | PAS domain-containing protein | - |
| QQA29_RS25850 (62927) | 62927..63310 | - | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| QQA29_RS25855 (63632) | 63632..64234 | + | 603 | WP_023145258.1 | transglycosylase SLT domain-containing protein | - |
| QQA29_RS25860 (64530) | 64530..65351 | - | 822 | WP_001234485.1 | DUF932 domain-containing protein | - |
| QQA29_RS25865 (65470) | 65470..65756 | - | 287 | Protein_76 | hypothetical protein | - |
| QQA29_RS25870 (65758) | 65758..66079 | + | 322 | Protein_77 | hypothetical protein | - |
| QQA29_RS25875 (66380) | 66380..66502 | - | 123 | WP_223195199.1 | Hok/Gef family protein | Toxin |
| QQA29_RS25880 (66447) | 66447..66560 | - | 114 | Protein_79 | DUF5431 family protein | - |
| - (66594) | 66594..66805 | - | 212 | NuclAT_0 | - | Antitoxin |
| - (66594) | 66594..66805 | - | 212 | NuclAT_0 | - | Antitoxin |
| - (66594) | 66594..66805 | - | 212 | NuclAT_0 | - | Antitoxin |
| - (66594) | 66594..66805 | - | 212 | NuclAT_0 | - | Antitoxin |
| QQA29_RS25885 (66816) | 66816..67535 | - | 720 | WP_001276275.1 | plasmid SOS inhibition protein A | - |
| QQA29_RS25890 (67532) | 67532..67966 | - | 435 | WP_000845935.1 | conjugation system SOS inhibitor PsiB | - |
| QQA29_RS25895 (68021) | 68021..69979 | - | 1959 | Protein_82 | ParB/RepB/Spo0J family partition protein | - |
| QQA29_RS25900 (70038) | 70038..70271 | - | 234 | WP_001209608.1 | DUF905 domain-containing protein | - |
| QQA29_RS25905 (70334) | 70334..70831 | - | 498 | WP_050427786.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD | iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat | 1..192699 | 192699 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 41 a.a. Molecular weight: 4536.35 Da Isoelectric Point: 8.2691
>T283225 WP_223195199.1 NZ_CP126943:c66502-66380 [Escherichia coli O1:K1:H7]
IVCCTLLIFTLLTRNRLCEVRLKDGYREVTASLAYESSGK
IVCCTLLIFTLLTRNRLCEVRLKDGYREVTASLAYESSGK
Download Length: 123 bp
Antitoxin
Download Length: 212 bp
>AT283225 NZ_CP126943:c66805-66594 [Escherichia coli O1:K1:H7]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTCTTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
AGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGC
AGAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGCCCCCTGTATGTCT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTCTTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
AGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGC
AGAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGCCCCCTGTATGTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
