Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4932070..4932672 Replicon chromosome
Accession NZ_CP126942
Organism Escherichia coli O1:K1:H7 strain APEC E18006

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QQA29_RS24305 Protein ID WP_000897302.1
Coordinates 4932361..4932672 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQA29_RS24300 Protein ID WP_000356397.1
Coordinates 4932070..4932360 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA29_RS24275 (4928143) 4928143..4929045 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QQA29_RS24280 (4929042) 4929042..4929677 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QQA29_RS24285 (4929674) 4929674..4930603 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QQA29_RS24290 (4930819) 4930819..4931037 - 219 WP_001314326.1 CopG family transcriptional regulator -
QQA29_RS24295 (4931433) 4931433..4931711 - 279 WP_001296612.1 hypothetical protein -
QQA29_RS24300 (4932070) 4932070..4932360 - 291 WP_000356397.1 NadS family protein Antitoxin
QQA29_RS24305 (4932361) 4932361..4932672 - 312 WP_000897302.1 hypothetical protein Toxin
QQA29_RS24310 (4932901) 4932901..4933809 + 909 WP_001331553.1 alpha/beta hydrolase -
QQA29_RS24315 (4933873) 4933873..4934814 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQA29_RS24320 (4934859) 4934859..4935296 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QQA29_RS24325 (4935293) 4935293..4936165 - 873 WP_000920754.1 virulence factor BrkB family protein -
QQA29_RS24330 (4936159) 4936159..4936758 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T283221 WP_000897302.1 NZ_CP126942:c4932672-4932361 [Escherichia coli O1:K1:H7]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT283221 WP_000356397.1 NZ_CP126942:c4932360-4932070 [Escherichia coli O1:K1:H7]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References